Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3475650..3476464 Replicon chromosome
Accession NZ_CP095526
Organism Escherichia coli strain GN05505

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag MW395_RS17815 Protein ID WP_001054376.1
Coordinates 3475650..3475907 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag MW395_RS17820 Protein ID WP_001309181.1
Coordinates 3475919..3476464 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW395_RS17790 (3470910) 3470910..3471890 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
MW395_RS17795 (3472000) 3472000..3472205 + 206 Protein_3337 HNH endonuclease -
MW395_RS17800 (3472505) 3472505..3473485 - 981 WP_000019400.1 IS5-like element IS5 family transposase -
MW395_RS17805 (3473672) 3473672..3474912 - 1241 Protein_3339 helicase YjhR -
MW395_RS17810 (3475028) 3475028..3475159 + 132 WP_001309182.1 hypothetical protein -
MW395_RS17815 (3475650) 3475650..3475907 + 258 WP_001054376.1 YjhX family toxin Toxin
MW395_RS17820 (3475919) 3475919..3476464 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
MW395_RS17825 (3476520) 3476520..3477266 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
MW395_RS17830 (3477435) 3477435..3477653 + 219 Protein_3344 hypothetical protein -
MW395_RS17835 (3477691) 3477691..3477807 + 117 Protein_3345 VOC family protein -
MW395_RS17840 (3478052) 3478052..3479173 + 1122 WP_000010829.1 M42 family metallopeptidase -
MW395_RS17845 (3479170) 3479170..3479448 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
MW395_RS17850 (3479460) 3479460..3480773 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3472505..3473485 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T242269 WP_001054376.1 NZ_CP095526:3475650-3475907 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T242269 NZ_OW052302:c1314675-1314241 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT242269 WP_001309181.1 NZ_CP095526:3475919-3476464 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT242269 NZ_OW052302:c1314860-1314681 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References