Detailed information of TA system TA242269

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3475650..3476464
• Replicon: chromosome
• Accession: NZ_CP095526
• Organism: Escherichia coli strain GN05505

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: MW395_RS17815
• Protein ID: WP_001054376.1
• Coordinates: 3475650..3475907 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: MW395_RS17820
• Protein ID: WP_001309181.1
• Coordinates: 3475919..3476464 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MW395_RS17790 (3470910)	3470910..3471890	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
MW395_RS17795 (3472000)	3472000..3472205	+	206	Protein_3337	HNH endonuclease	-
MW395_RS17800 (3472505)	3472505..3473485	-	981	WP_000019400.1	IS5-like element IS5 family transposase	-
MW395_RS17805 (3473672)	3473672..3474912	-	1241	Protein_3339	helicase YjhR	-
MW395_RS17810 (3475028)	3475028..3475159	+	132	WP_001309182.1	hypothetical protein	-
MW395_RS17815 (3475650)	3475650..3475907	+	258	WP_001054376.1	YjhX family toxin	Toxin
MW395_RS17820 (3475919)	3475919..3476464	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
MW395_RS17825 (3476520)	3476520..3477266	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
MW395_RS17830 (3477435)	3477435..3477653	+	219	Protein_3344	hypothetical protein	-
MW395_RS17835 (3477691)	3477691..3477807	+	117	Protein_3345	VOC family protein	-
MW395_RS17840 (3478052)	3478052..3479173	+	1122	WP_000010829.1	M42 family metallopeptidase	-
MW395_RS17845 (3479170)	3479170..3479448	+	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
MW395_RS17850 (3479460)	3479460..3480773	+	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View CP009789 Escherichia coli K-12 strain ER3413 IS/Tn TA006348 3666255..3667235 0.003 View NC_000913 Escherichia coli str. K-12 substr. MG1655 IS/Tn TA006364 3652182..3653162 0.003	flank	IS/Tn	-	-	3472505..3473485	980

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T242269 WP_001054376.1 NZ_CP095526:3475650-3475907 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T242269 NZ_OW052302:c1314675-1314241 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT242269 WP_001309181.1 NZ_CP095526:3475919-3476464 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT242269 NZ_OW052302:c1314860-1314681 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8