Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3956129..3956943 Replicon chromosome
Accession NZ_CP074359
Organism Escherichia coli strain XJ6.2

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag KFQ22_RS19245 Protein ID WP_001054376.1
Coordinates 3956129..3956386 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag KFQ22_RS19250 Protein ID WP_001309181.1
Coordinates 3956398..3956943 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFQ22_RS19220 (3951389) 3951389..3952369 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
KFQ22_RS19225 (3952479) 3952479..3952684 + 206 Protein_3755 HNH endonuclease -
KFQ22_RS19230 (3952984) 3952984..3953964 - 981 WP_000019400.1 IS5-like element IS5 family transposase -
KFQ22_RS19235 (3954151) 3954151..3955391 - 1241 Protein_3757 helicase YjhR -
KFQ22_RS19240 (3955507) 3955507..3955638 + 132 WP_001309182.1 hypothetical protein -
KFQ22_RS19245 (3956129) 3956129..3956386 + 258 WP_001054376.1 YjhX family toxin Toxin
KFQ22_RS19250 (3956398) 3956398..3956943 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
KFQ22_RS19255 (3956999) 3956999..3957745 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
KFQ22_RS19260 (3957914) 3957914..3958132 + 219 Protein_3762 hypothetical protein -
KFQ22_RS19265 (3958170) 3958170..3958286 + 117 Protein_3763 VOC family protein -
KFQ22_RS19270 (3958531) 3958531..3959652 + 1122 WP_000010829.1 M42 family metallopeptidase -
KFQ22_RS19275 (3959649) 3959649..3959927 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
KFQ22_RS19280 (3959939) 3959939..3961252 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimC / fimI / fimA / fimE / fimB 3943955..3965167 21212
flank IS/Tn - - 3952984..3953964 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T201945 WP_001054376.1 NZ_CP074359:3956129-3956386 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T201945 NZ_CP099128:1978547-1978650 [Citrobacter freundii]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT201945 WP_001309181.1 NZ_CP074359:3956398-3956943 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT201945 NZ_CP099128:c1978655-1978512 [Citrobacter freundii]
CACATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References