Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4381781..4382595 Replicon chromosome
Accession NZ_CP104665
Organism Escherichia coli strain 2021CK-00607

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag N5914_RS21065 Protein ID WP_001054376.1
Coordinates 4381781..4382038 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag N5914_RS21070 Protein ID WP_001309181.1
Coordinates 4382050..4382595 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5914_RS21040 (4377041) 4377041..4378021 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
N5914_RS21045 (4378131) 4378131..4378336 + 206 Protein_4125 HNH endonuclease -
N5914_RS21050 (4378636) 4378636..4379616 - 981 WP_000019400.1 IS5-like element IS5 family transposase -
N5914_RS21055 (4379803) 4379803..4381043 - 1241 Protein_4127 helicase YjhR -
N5914_RS21060 (4381159) 4381159..4381290 + 132 WP_001309182.1 hypothetical protein -
N5914_RS21065 (4381781) 4381781..4382038 + 258 WP_001054376.1 YjhX family toxin Toxin
N5914_RS21070 (4382050) 4382050..4382595 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
N5914_RS21075 (4382651) 4382651..4383397 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
N5914_RS21080 (4383566) 4383566..4383784 + 219 Protein_4132 hypothetical protein -
N5914_RS21085 (4383822) 4383822..4383938 + 117 Protein_4133 VOC family protein -
N5914_RS21090 (4384183) 4384183..4385304 + 1122 WP_000010829.1 M42 family metallopeptidase -
N5914_RS21095 (4385301) 4385301..4385579 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
N5914_RS21100 (4385591) 4385591..4386904 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4373076..4390819 17743
flank IS/Tn - - 4378636..4379616 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T258932 WP_001054376.1 NZ_CP104665:4381781-4382038 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT258932 WP_001309181.1 NZ_CP104665:4382050-4382595 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References