Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3456658..3457276 | Replicon | chromosome |
Accession | NZ_CP046025 | ||
Organism | Escherichia coli strain C439 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | H5UYE2 |
Locus tag | GJH08_RS16820 | Protein ID | WP_001291435.1 |
Coordinates | 3457058..3457276 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | S1PTH5 |
Locus tag | GJH08_RS16815 | Protein ID | WP_000344800.1 |
Coordinates | 3456658..3457032 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GJH08_RS16805 | 3451764..3454913 | + | 3150 | WP_001132469.1 | multidrug efflux RND transporter permease subunit | - |
GJH08_RS16810 | 3455406..3456422 | + | 1017 | WP_010723085.1 | IS5-like element IS5 family transposase | - |
GJH08_RS16815 | 3456658..3457032 | + | 375 | WP_000344800.1 | Hha toxicity modulator TomB | Antitoxin |
GJH08_RS16820 | 3457058..3457276 | + | 219 | WP_001291435.1 | hemolysin expression modulator Hha | Toxin |
GJH08_RS16825 | 3457448..3457999 | + | 552 | WP_000102564.1 | maltose O-acetyltransferase | - |
GJH08_RS16830 | 3458115..3458585 | + | 471 | WP_000136192.1 | YlaC family protein | - |
GJH08_RS16835 | 3458749..3460299 | + | 1551 | WP_001310610.1 | cyclic-guanylate-specific phosphodiesterase PdeB | - |
GJH08_RS16840 | 3460341..3460694 | - | 354 | WP_000878140.1 | DUF1428 domain-containing protein | - |
GJH08_RS16850 | 3461073..3461384 | + | 312 | WP_000409911.1 | MGMT family protein | - |
GJH08_RS16855 | 3461415..3461987 | - | 573 | WP_000779842.1 | YbaY family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
flank | IS/Tn | - | - | 3455442..3456422 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T143417 WP_001291435.1 NZ_CP046025:3457058-3457276 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T143417 NZ_CP061082:c1108328-1108125 [Serratia liquefaciens]
ATGACTAAAACTGATTATCTGATGCGTTTACGTAAATGCACCACTATTGACACCCTTGAACGCGTTATTGAAAAAAATAA
GTATGAGCTTTCGGATGACGAATTGGAGCTGTTTTACTCTGCAGCTGACCACCGTCTGGCTGAGCTCACCATGAATAAGC
TCTACGATAAAATCCCAACGGCCGTTTGGAAGTTCGTACGTTAA
ATGACTAAAACTGATTATCTGATGCGTTTACGTAAATGCACCACTATTGACACCCTTGAACGCGTTATTGAAAAAAATAA
GTATGAGCTTTCGGATGACGAATTGGAGCTGTTTTACTCTGCAGCTGACCACCGTCTGGCTGAGCTCACCATGAATAAGC
TCTACGATAAAATCCCAACGGCCGTTTGGAAGTTCGTACGTTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14557.39 Da Isoelectric Point: 4.7395
>AT143417 WP_000344800.1 NZ_CP046025:3456658-3457032 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
Download Length: 375 bp
>AT143417 NZ_CP061082:c1108752-1108384 [Serratia liquefaciens]
ATGGATGAGTATTCGCCTAAAAGGCACGATATTGCTCAGCTGAAATTCTTGTGCGAAAATTTGTATGATGAAGGCATAGC
CACGCTGGGCGACAGCCACCACGGCTGGGTGAACGACCCAACGTCTTCCGTCAACCTCCAGCTTAATGAGTTGATTGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAAAGTGATTTATCGGAGTTAGTCGAGGAATATCTC
GATGATACCTACACGCTGTTCAGCAGTTACGGTATCAATGATTCCGATCTGCGTCGCTGGCAAAAAACCAAGGCGCGATT
ATTCAGAATGTTCTCAGGAGAGGGCATCTGTACGACAATGAAATCTTAG
ATGGATGAGTATTCGCCTAAAAGGCACGATATTGCTCAGCTGAAATTCTTGTGCGAAAATTTGTATGATGAAGGCATAGC
CACGCTGGGCGACAGCCACCACGGCTGGGTGAACGACCCAACGTCTTCCGTCAACCTCCAGCTTAATGAGTTGATTGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAAAGTGATTTATCGGAGTTAGTCGAGGAATATCTC
GATGATACCTACACGCTGTTCAGCAGTTACGGTATCAATGATTCCGATCTGCGTCGCTGGCAAAAAACCAAGGCGCGATT
ATTCAGAATGTTCTCAGGAGAGGGCATCTGTACGACAATGAAATCTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 2MW2 | |
PDB | 1JW2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QBQ5 |