Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yjhX-yjhQ/YjhX-GNAT |
Location | 4269356..4270170 | Replicon | chromosome |
Accession | NZ_CP095155 | ||
Organism | Escherichia coli strain Iso00041 |
Toxin (Protein)
Gene name | yjhX | Uniprot ID | S1PA82 |
Locus tag | MU410_RS20595 | Protein ID | WP_001054376.1 |
Coordinates | 4269356..4269613 (+) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | yjhQ | Uniprot ID | U9Z4B8 |
Locus tag | MU410_RS20600 | Protein ID | WP_001309181.1 |
Coordinates | 4269625..4270170 (+) | Length | 182 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MU410_RS20570 (4264616) | 4264616..4265596 | + | 981 | WP_000991438.1 | 9-O-acetyl-N-acetylneuraminic acid deacetylase | - |
MU410_RS20575 (4265706) | 4265706..4265911 | + | 206 | Protein_4040 | HNH endonuclease | - |
MU410_RS20580 (4266211) | 4266211..4267191 | - | 981 | WP_000019400.1 | IS5-like element IS5 family transposase | - |
MU410_RS20585 (4267378) | 4267378..4268618 | - | 1241 | Protein_4042 | helicase YjhR | - |
MU410_RS20590 (4268734) | 4268734..4268865 | + | 132 | WP_001309182.1 | hypothetical protein | - |
MU410_RS20595 (4269356) | 4269356..4269613 | + | 258 | WP_001054376.1 | YjhX family toxin | Toxin |
MU410_RS20600 (4269625) | 4269625..4270170 | + | 546 | WP_001309181.1 | N-acetyltransferase | Antitoxin |
MU410_RS20605 (4270226) | 4270226..4270972 | + | 747 | WP_000354251.1 | class I SAM-dependent methyltransferase | - |
MU410_RS20610 (4271141) | 4271141..4271359 | + | 219 | Protein_4047 | hypothetical protein | - |
MU410_RS20615 (4271397) | 4271397..4271513 | + | 117 | Protein_4048 | VOC family protein | - |
MU410_RS20620 (4271758) | 4271758..4272879 | + | 1122 | WP_000010829.1 | M42 family metallopeptidase | - |
MU410_RS20625 (4272876) | 4272876..4273154 | + | 279 | WP_000722973.1 | PTS sugar transporter subunit IIB SgcB | - |
MU410_RS20630 (4273166) | 4273166..4274479 | + | 1314 | WP_000460843.1 | PTS sugar transporter subunit IIC SgcC | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | fimB | 4260651..4278394 | 17743 | |
flank | IS/Tn | - | - | 4266211..4267191 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9734.29 Da Isoelectric Point: 11.0090
>T241586 WP_001054376.1 NZ_CP095155:4269356-4269613 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR
Download Length: 258 bp
>T241586 NZ_LT992491:816339-816656 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAACGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTAGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAGAC
TTTATTCTCATTGTTGCAGTATTAGGGCAATCACAGCTGCCCCAAAAGCATCTCAAACACTCACGCTTTGTTTCTTAG
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAACGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTAGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAGAC
TTTATTCTCATTGTTGCAGTATTAGGGCAATCACAGCTGCCCCAAAAGCATCTCAAACACTCACGCTTTGTTTCTTAG
Antitoxin
Download Length: 182 a.a. Molecular weight: 19956.90 Da Isoelectric Point: 6.3277
>AT241586 WP_001309181.1 NZ_CP095155:4269625-4270170 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT
Download Length: 546 bp
>AT241586 NZ_LT992491:816078-816320 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAGCGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCCATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTCGATGGTGCCGCTTTTCTAAACACCCTT
TGA
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAGCGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCCATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTCGATGGTGCCGCTTTTCTAAACACCCTT
TGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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