Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4269356..4270170 Replicon chromosome
Accession NZ_CP095155
Organism Escherichia coli strain Iso00041

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag MU410_RS20595 Protein ID WP_001054376.1
Coordinates 4269356..4269613 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag MU410_RS20600 Protein ID WP_001309181.1
Coordinates 4269625..4270170 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU410_RS20570 (4264616) 4264616..4265596 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
MU410_RS20575 (4265706) 4265706..4265911 + 206 Protein_4040 HNH endonuclease -
MU410_RS20580 (4266211) 4266211..4267191 - 981 WP_000019400.1 IS5-like element IS5 family transposase -
MU410_RS20585 (4267378) 4267378..4268618 - 1241 Protein_4042 helicase YjhR -
MU410_RS20590 (4268734) 4268734..4268865 + 132 WP_001309182.1 hypothetical protein -
MU410_RS20595 (4269356) 4269356..4269613 + 258 WP_001054376.1 YjhX family toxin Toxin
MU410_RS20600 (4269625) 4269625..4270170 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
MU410_RS20605 (4270226) 4270226..4270972 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
MU410_RS20610 (4271141) 4271141..4271359 + 219 Protein_4047 hypothetical protein -
MU410_RS20615 (4271397) 4271397..4271513 + 117 Protein_4048 VOC family protein -
MU410_RS20620 (4271758) 4271758..4272879 + 1122 WP_000010829.1 M42 family metallopeptidase -
MU410_RS20625 (4272876) 4272876..4273154 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
MU410_RS20630 (4273166) 4273166..4274479 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4260651..4278394 17743
flank IS/Tn - - 4266211..4267191 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T241586 WP_001054376.1 NZ_CP095155:4269356-4269613 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T241586 NZ_LT992491:816339-816656 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAACGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTAGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAGAC
TTTATTCTCATTGTTGCAGTATTAGGGCAATCACAGCTGCCCCAAAAGCATCTCAAACACTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT241586 WP_001309181.1 NZ_CP095155:4269625-4270170 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT241586 NZ_LT992491:816078-816320 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAGCGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCCATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTCGATGGTGCCGCTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References