Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4129128..4129942 Replicon chromosome
Accession NZ_LR890288
Organism Escherichia coli isolate MSB1_1A-sc-2280383

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag JMW08_RS19620 Protein ID WP_001054376.1
Coordinates 4129128..4129385 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag JMW08_RS19625 Protein ID WP_001309181.1
Coordinates 4129397..4129942 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW08_RS19600 4124388..4125368 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
JMW08_RS19605 4125983..4126999 - 1017 WP_001322394.1 IS5-like element IS5 family transposase -
JMW08_RS19610 4127150..4128390 - 1241 Protein_3831 DNA helicase -
JMW08_RS19615 4128506..4128751 + 246 Protein_3832 GNAT family N-acetyltransferase -
JMW08_RS19620 4129128..4129385 + 258 WP_001054376.1 hypothetical protein Toxin
JMW08_RS19625 4129397..4129942 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
JMW08_RS19630 4129998..4130744 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
JMW08_RS19635 4130913..4131131 + 219 Protein_3836 hypothetical protein -
JMW08_RS19640 4131169..4131285 + 117 Protein_3837 VOC family protein -
JMW08_RS19645 4131530..4132651 + 1122 WP_000010829.1 M42 family metallopeptidase -
JMW08_RS19650 4132648..4132926 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
JMW08_RS19655 4132938..4134251 + 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4120423..4138166 17743
flank IS/Tn - - 4125983..4126963 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T290513 WP_001054376.1 NZ_LR890288:4129128-4129385 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT290513 WP_001309181.1 NZ_LR890288:4129397-4129942 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References