Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4131902..4132716 Replicon chromosome
Accession NZ_LR890603
Organism Escherichia coli isolate MSB1_8G-sc-2280388

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag JMW40_RS19630 Protein ID WP_001054376.1
Coordinates 4131902..4132159 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag JMW40_RS19635 Protein ID WP_001309181.1
Coordinates 4132171..4132716 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW40_RS19610 4127162..4128142 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
JMW40_RS19615 4128757..4129773 - 1017 WP_001322394.1 IS5-like element IS5 family transposase -
JMW40_RS19620 4129924..4131164 - 1241 Protein_3833 DNA helicase -
JMW40_RS19625 4131280..4131525 + 246 Protein_3834 GNAT family N-acetyltransferase -
JMW40_RS19630 4131902..4132159 + 258 WP_001054376.1 hypothetical protein Toxin
JMW40_RS19635 4132171..4132716 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
JMW40_RS19640 4132772..4133518 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
JMW40_RS19645 4133687..4133905 + 219 Protein_3838 hypothetical protein -
JMW40_RS19650 4133943..4134059 + 117 Protein_3839 VOC family protein -
JMW40_RS19655 4134304..4135425 + 1122 WP_000010829.1 M42 family metallopeptidase -
JMW40_RS19660 4135422..4135700 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
JMW40_RS19665 4135712..4137025 + 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 4120489..4140940 20451
flank IS/Tn - - 4128757..4129737 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T291532 WP_001054376.1 NZ_LR890603:4131902-4132159 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT291532 WP_001309181.1 NZ_LR890603:4132171-4132716 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References