Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4283556..4284370 Replicon chromosome
Accession NZ_CP117053
Organism Escherichia coli strain MLI106K4

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag NL407_RS21880 Protein ID WP_001054376.1
Coordinates 4283556..4283813 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag NL407_RS21885 Protein ID WP_001309181.1
Coordinates 4283825..4284370 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL407_RS21855 (4278816) 4278816..4279796 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
NL407_RS21860 (4279906) 4279906..4280111 + 206 Protein_4057 HNH endonuclease -
NL407_RS21865 (4280411) 4280411..4281391 - 981 WP_000019400.1 IS5-like element IS5 family transposase -
NL407_RS21870 (4281578) 4281578..4282818 - 1241 Protein_4059 helicase YjhR -
NL407_RS21875 (4282934) 4282934..4283065 + 132 WP_001309182.1 hypothetical protein -
NL407_RS21880 (4283556) 4283556..4283813 + 258 WP_001054376.1 YjhX family toxin Toxin
NL407_RS21885 (4283825) 4283825..4284370 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
NL407_RS21890 (4284426) 4284426..4285172 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
NL407_RS21895 (4285341) 4285341..4285559 + 219 Protein_4064 hypothetical protein -
NL407_RS21900 (4285597) 4285597..4285713 + 117 Protein_4065 VOC family protein -
NL407_RS21905 (4285958) 4285958..4287079 + 1122 WP_000010829.1 M42 family metallopeptidase -
NL407_RS21910 (4287076) 4287076..4287354 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
NL407_RS21915 (4287366) 4287366..4288679 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 4272143..4292594 20451
flank IS/Tn - - 4280411..4281391 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T269974 WP_001054376.1 NZ_CP117053:4283556-4283813 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT269974 WP_001309181.1 NZ_CP117053:4283825-4284370 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References