Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 5075112..5075926 Replicon chromosome
Accession NZ_CP032515
Organism Escherichia coli strain 118UI

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag Eco118UI_RS25370 Protein ID WP_001054376.1
Coordinates 5075669..5075926 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag Eco118UI_RS25365 Protein ID WP_001309181.1
Coordinates 5075112..5075657 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Eco118UI_RS25340 5070803..5072116 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
Eco118UI_RS25345 5072128..5072406 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
Eco118UI_RS25350 5072403..5073524 - 1122 WP_000010829.1 M42 family metallopeptidase -
Eco118UI_RS26935 5073769..5073885 - 117 Protein_4778 VOC family protein -
Eco118UI_RS25355 5073923..5074141 - 219 Protein_4779 hypothetical protein -
Eco118UI_RS25360 5074310..5075056 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
Eco118UI_RS25365 5075112..5075657 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
Eco118UI_RS25370 5075669..5075926 - 258 WP_001054376.1 hypothetical protein Toxin
Eco118UI_RS25380 5076303..5076548 - 246 Protein_4783 GNAT family N-acetyltransferase -
Eco118UI_RS25390 5076664..5077904 + 1241 Protein_4784 helicase YjhR -
Eco118UI_RS25395 5078091..5079071 + 981 WP_000019400.1 IS5-like element IS5 family transposase -
Eco118UI_RS25405 5079686..5080666 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 5078091..5079071 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T111915 WP_001054376.1 NZ_CP032515:c5075926-5075669 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T111915 NZ_CP032515:c5075926-5075669 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT111915 WP_001309181.1 NZ_CP032515:c5075657-5075112 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT111915 NZ_CP032515:c5075657-5075112 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References