Detailed information of TA system TA111915

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 5075112..5075926
• Replicon: chromosome
• Accession: NZ_CP032515
• Organism: Escherichia coli strain 118UI

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: Eco118UI_RS25370
• Protein ID: WP_001054376.1
• Coordinates: 5075669..5075926 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: Eco118UI_RS25365
• Protein ID: WP_001309181.1
• Coordinates: 5075112..5075657 (-)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Eco118UI_RS25340	5070803..5072116	-	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-
Eco118UI_RS25345	5072128..5072406	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
Eco118UI_RS25350	5072403..5073524	-	1122	WP_000010829.1	M42 family metallopeptidase	-
Eco118UI_RS26935	5073769..5073885	-	117	Protein_4778	VOC family protein	-
Eco118UI_RS25355	5073923..5074141	-	219	Protein_4779	hypothetical protein	-
Eco118UI_RS25360	5074310..5075056	-	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
Eco118UI_RS25365	5075112..5075657	-	546	WP_001309181.1	N-acetyltransferase	Antitoxin
Eco118UI_RS25370	5075669..5075926	-	258	WP_001054376.1	hypothetical protein	Toxin
Eco118UI_RS25380	5076303..5076548	-	246	Protein_4783	GNAT family N-acetyltransferase	-
Eco118UI_RS25390	5076664..5077904	+	1241	Protein_4784	helicase YjhR	-
Eco118UI_RS25395	5078091..5079071	+	981	WP_000019400.1	IS5-like element IS5 family transposase	-
Eco118UI_RS25405	5079686..5080666	-	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View CP009789 Escherichia coli K-12 strain ER3413 IS/Tn TA006348 3666255..3667235 0.003 View NC_000913 Escherichia coli str. K-12 substr. MG1655 IS/Tn TA006364 3652182..3653162 0.003	flank	IS/Tn	-	-	5078091..5079071	980

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T111915 WP_001054376.1 NZ_CP032515:c5075926-5075669 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T111915 NZ_CP032515:c5075926-5075669 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT111915 WP_001309181.1 NZ_CP032515:c5075657-5075112 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT111915 NZ_CP032515:c5075657-5075112 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8