Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 4422334..4422556 Replicon chromosome
Accession NZ_CP010443
Organism Escherichia coli K-12 strain K-12 MG1655

Toxin (Protein)


Gene name ldrD Uniprot ID S1E8T8
Locus tag SH04_RS21880 Protein ID WP_000141634.1
Coordinates 4422334..4422441 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 4422490..4422556 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SH04_RS21860 4417731..4418747 - 1017 WP_010723085.1 IS5-like element IS5 family transposase -
SH04_RS21865 4418812..4420383 + 1572 WP_001204931.1 cellulose biosynthesis protein BcsE -
SH04_RS21870 4420380..4420571 + 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
SH04_RS21875 4420568..4422247 + 1680 WP_000191622.1 cellulose biosynthesis protein BcsG -
SH04_RS21880 4422334..4422441 - 108 WP_000141634.1 type I toxin-antitoxin system toxic polypeptide LdrD Toxin
- 4422490..4422556 + 67 - - Antitoxin
SH04_RS21890 4422917..4424188 + 1272 WP_001295225.1 transporter -
SH04_RS21895 4424218..4425222 - 1005 WP_000107012.1 dipeptide ABC transporter ATP-binding subunit DppF -
SH04_RS21900 4425219..4426202 - 984 WP_001196486.1 dipeptide ABC transporter ATP-binding protein -
SH04_RS21905 4426213..4427115 - 903 WP_000084677.1 dipeptide ABC transporter permease DppC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4417731..4418711 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3916.72 Da        Isoelectric Point: 9.0157

>T52649 WP_000141634.1 NZ_CP010443:c4422441-4422334 [Escherichia coli K-12]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Download         Length: 108 bp

>T52649 NZ_CP010443:c4422441-4422334 [Escherichia coli K-12]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 67 bp

>AT52649 NZ_CP010443:4422490-4422556 [Escherichia coli K-12]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5LBJ

Antitoxin

Download structure file

References