246985

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4336972..4337786 Replicon chromosome
Accession NZ_CP098197
Organism Escherichia coli strain Z0117EC0062

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag NBY21_RS20640 Protein ID WP_001054376.1
Coordinates 4336972..4337229 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag NBY21_RS20645 Protein ID WP_001309181.1
Coordinates 4337241..4337786 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY21_RS20615 (4332232) 4332232..4333212 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
NBY21_RS20620 (4333322) 4333322..4333527 + 206 Protein_4035 HNH endonuclease -
NBY21_RS20625 (4333827) 4333827..4334807 - 981 WP_000019400.1 IS5-like element IS5 family transposase -
NBY21_RS20630 (4334994) 4334994..4336234 - 1241 Protein_4037 helicase YjhR -
NBY21_RS20635 (4336350) 4336350..4336481 + 132 WP_001309182.1 hypothetical protein -
NBY21_RS20640 (4336972) 4336972..4337229 + 258 WP_001054376.1 YjhX family toxin Toxin
NBY21_RS20645 (4337241) 4337241..4337786 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
NBY21_RS20650 (4337842) 4337842..4338588 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
NBY21_RS20655 (4338757) 4338757..4338975 + 219 Protein_4042 hypothetical protein -
NBY21_RS20660 (4339013) 4339013..4339129 + 117 Protein_4043 VOC family protein -
NBY21_RS20665 (4339374) 4339374..4340495 + 1122 WP_000010829.1 M42 family metallopeptidase -
NBY21_RS20670 (4340492) 4340492..4340770 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
NBY21_RS20675 (4340782) 4340782..4342095 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4328267..4346010 17743
flank IS/Tn - - 4333827..4334807 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T246985 WP_001054376.1 NZ_CP098197:4336972-4337229 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT246985 WP_001309181.1 NZ_CP098197:4337241-4337786 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References