Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 94523..95148 Replicon plasmid unnamednovel_0
Accession NZ_CP062900
Organism Escherichia coli strain Res13-Lact-ER02-39

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IMP38_RS24575 Protein ID WP_000911317.1
Coordinates 94750..95148 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag IMP38_RS24570 Protein ID WP_000450532.1
Coordinates 94523..94750 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP38_RS24565 89922..94441 - 4520 Protein_101 conjugative transfer relaxase/helicase TraI -
IMP38_RS24570 94523..94750 + 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin
IMP38_RS24575 94750..95148 + 399 WP_000911317.1 tRNA(fMet)-specific endonuclease VapC Toxin
IMP38_RS24580 95157..97310 - 2154 WP_195686652.1 type IV conjugative transfer system coupling protein TraD -
IMP38_RS24585 97562..98293 - 732 WP_000850430.1 complement resistance protein TraT -
IMP38_RS24590 98325..98635 - 311 Protein_106 entry exclusion protein -
IMP38_RS24595 98668..99684 + 1017 WP_001322394.1 IS5-like element IS5 family transposase -
IMP38_RS24600 99832..100014 - 183 Protein_108 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..141262 141262
flank IS/Tn - - 98704..99684 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14857.14 Da        Isoelectric Point: 8.5264

>T177218 WP_000911317.1 NZ_CP062900:94750-95148 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

>T177218 NZ_CP083348:131026-131445 [Ensifer adhaerens]
ATGATCGTTCTGGACACAAATGTCGTCTCGGAAGCGATGAAGCCGGCCCCGGATTTAGCCGTGCGTAATTGGTTAAATGA
TCAAGTGGCTGAAACCTTGTATCTGTCCAGTGTGACGCTGGCGGAGTTACTCTTTGGCATTGCTGCGCTGCCGGAGGGAC
GGCGCAAAAAGGCGTTGGCCGAAACTCTTGATGGTATGCTCGAACTGTTTGATGATCGCGTGTTGCCATTCGACACTGCA
GCCGCTCGGCACTATGCCGACCTTGCGGCAATCGCGCGAGCGGCGGGGAAGGGATTTCCGACACCTGATGGTTACATTGT
CGCTATCGCAGCCTCCAGGGGGTTTATAATCGCAACACGCGATACAAGCCCTTTTGAGGCGGCAGGTCTCTCCGTCGTAA
ATCCTTGGAGTGACCTATAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT177218 WP_000450532.1 NZ_CP062900:94523-94750 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp

>AT177218 NZ_CP083348:130775-131029 [Ensifer adhaerens]
ATGGCGATCCTGACGGTACGAAATGTGCCTGATGAAGTGCACCGCGCTTTGCGTGTCCGGGCGGCGATTCACGGCCGCAG
CACAGAGGCGGAAGTCCGCGAGATTTTGGAACGTGCGGTCAAGCCCGAACAGCGTGTCCGCATAGGCGACGCCTTGGCTG
AGCTGAGCGGGCGGCTTGGCCTGACCAATGAGGATTTTGAAGTGTTCGACCAGGTGCGAGACAAAGTGCCGGCTGAGCCA
ATGAGGTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References