Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VagC |
Location | 94523..95148 | Replicon | plasmid unnamednovel_0 |
Accession | NZ_CP062900 | ||
Organism | Escherichia coli strain Res13-Lact-ER02-39 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | IMP38_RS24575 | Protein ID | WP_000911317.1 |
Coordinates | 94750..95148 (+) | Length | 133 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | L4J1D2 |
Locus tag | IMP38_RS24570 | Protein ID | WP_000450532.1 |
Coordinates | 94523..94750 (+) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IMP38_RS24565 | 89922..94441 | - | 4520 | Protein_101 | conjugative transfer relaxase/helicase TraI | - |
IMP38_RS24570 | 94523..94750 | + | 228 | WP_000450532.1 | toxin-antitoxin system antitoxin VapB | Antitoxin |
IMP38_RS24575 | 94750..95148 | + | 399 | WP_000911317.1 | tRNA(fMet)-specific endonuclease VapC | Toxin |
IMP38_RS24580 | 95157..97310 | - | 2154 | WP_195686652.1 | type IV conjugative transfer system coupling protein TraD | - |
IMP38_RS24585 | 97562..98293 | - | 732 | WP_000850430.1 | complement resistance protein TraT | - |
IMP38_RS24590 | 98325..98635 | - | 311 | Protein_106 | entry exclusion protein | - |
IMP38_RS24595 | 98668..99684 | + | 1017 | WP_001322394.1 | IS5-like element IS5 family transposase | - |
IMP38_RS24600 | 99832..100014 | - | 183 | Protein_108 | entry exclusion protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..141262 | 141262 | |
flank | IS/Tn | - | - | 98704..99684 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 14857.14 Da Isoelectric Point: 8.5264
>T177218 WP_000911317.1 NZ_CP062900:94750-95148 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS
Download Length: 399 bp
>T177218 NZ_CP083348:131026-131445 [Ensifer adhaerens]
ATGATCGTTCTGGACACAAATGTCGTCTCGGAAGCGATGAAGCCGGCCCCGGATTTAGCCGTGCGTAATTGGTTAAATGA
TCAAGTGGCTGAAACCTTGTATCTGTCCAGTGTGACGCTGGCGGAGTTACTCTTTGGCATTGCTGCGCTGCCGGAGGGAC
GGCGCAAAAAGGCGTTGGCCGAAACTCTTGATGGTATGCTCGAACTGTTTGATGATCGCGTGTTGCCATTCGACACTGCA
GCCGCTCGGCACTATGCCGACCTTGCGGCAATCGCGCGAGCGGCGGGGAAGGGATTTCCGACACCTGATGGTTACATTGT
CGCTATCGCAGCCTCCAGGGGGTTTATAATCGCAACACGCGATACAAGCCCTTTTGAGGCGGCAGGTCTCTCCGTCGTAA
ATCCTTGGAGTGACCTATAG
ATGATCGTTCTGGACACAAATGTCGTCTCGGAAGCGATGAAGCCGGCCCCGGATTTAGCCGTGCGTAATTGGTTAAATGA
TCAAGTGGCTGAAACCTTGTATCTGTCCAGTGTGACGCTGGCGGAGTTACTCTTTGGCATTGCTGCGCTGCCGGAGGGAC
GGCGCAAAAAGGCGTTGGCCGAAACTCTTGATGGTATGCTCGAACTGTTTGATGATCGCGTGTTGCCATTCGACACTGCA
GCCGCTCGGCACTATGCCGACCTTGCGGCAATCGCGCGAGCGGCGGGGAAGGGATTTCCGACACCTGATGGTTACATTGT
CGCTATCGCAGCCTCCAGGGGGTTTATAATCGCAACACGCGATACAAGCCCTTTTGAGGCGGCAGGTCTCTCCGTCGTAA
ATCCTTGGAGTGACCTATAG
Antitoxin
Download Length: 76 a.a. Molecular weight: 8512.55 Da Isoelectric Point: 4.5358
>AT177218 WP_000450532.1 NZ_CP062900:94523-94750 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF
Download Length: 228 bp
>AT177218 NZ_CP083348:130775-131029 [Ensifer adhaerens]
ATGGCGATCCTGACGGTACGAAATGTGCCTGATGAAGTGCACCGCGCTTTGCGTGTCCGGGCGGCGATTCACGGCCGCAG
CACAGAGGCGGAAGTCCGCGAGATTTTGGAACGTGCGGTCAAGCCCGAACAGCGTGTCCGCATAGGCGACGCCTTGGCTG
AGCTGAGCGGGCGGCTTGGCCTGACCAATGAGGATTTTGAAGTGTTCGACCAGGTGCGAGACAAAGTGCCGGCTGAGCCA
ATGAGGTTTGAATGA
ATGGCGATCCTGACGGTACGAAATGTGCCTGATGAAGTGCACCGCGCTTTGCGTGTCCGGGCGGCGATTCACGGCCGCAG
CACAGAGGCGGAAGTCCGCGAGATTTTGGAACGTGCGGTCAAGCCCGAACAGCGTGTCCGCATAGGCGACGCCTTGGCTG
AGCTGAGCGGGCGGCTTGGCCTGACCAATGAGGATTTTGAAGTGTTCGACCAGGTGCGAGACAAAGTGCCGGCTGAGCCA
ATGAGGTTTGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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