177145

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 94515..95140 Replicon plasmid unnamednovel_0
Accession NZ_CP062888
Organism Escherichia coli strain Res13-Lact-PEA06-10

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IMP66_RS24610 Protein ID WP_000911317.1
Coordinates 94742..95140 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag IMP66_RS24605 Protein ID WP_000450532.1
Coordinates 94515..94742 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP66_RS24600 89914..94433 - 4520 Protein_101 conjugative transfer relaxase/helicase TraI -
IMP66_RS24605 94515..94742 + 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin
IMP66_RS24610 94742..95140 + 399 WP_000911317.1 tRNA(fMet)-specific endonuclease VapC Toxin
IMP66_RS24615 95149..97302 - 2154 WP_195686652.1 type IV conjugative transfer system coupling protein TraD -
IMP66_RS24620 97554..98285 - 732 WP_000850430.1 complement resistance protein TraT -
IMP66_RS24625 98317..98627 - 311 Protein_106 entry exclusion protein -
IMP66_RS24630 98660..99676 + 1017 WP_001322394.1 IS5-like element IS5 family transposase -
IMP66_RS24635 99824..100006 - 183 Protein_108 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..141254 141254
flank IS/Tn - - 98696..99676 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14857.14 Da        Isoelectric Point: 8.5264

>T177145 WP_000911317.1 NZ_CP062888:94742-95140 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

>T177145 NZ_CP083257:c1019736-1019413 [Bifidobacterium longum subsp. longum]
ATGAAACGAGGTGAGATTTGGACGTTGCAGGCCGATGGCTACGCCAGCAAGCCACGGCCGGTTGTCATCGTGCAGAGCGA
TGCCGTCGATCGGTTCGATTCCGTCATCACTTGTCTGCTGACCTCATACGATTCCTCCGACATCGACACGCGGGTCCGAT
TGGAACCAAGTCCGGAGAACGGCCTGAACAAAGTGAGTTACGTGATGACGGACAAGATCGTCACCGTCGACCGCAAACTG
CTGGGATACCAAGTCGGCGTGGTTGATGATGCAGCCATGGCGAATATCGGCCGTCAGCTCATGCGGATTCTAGGTTTGCT
GTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT177145 WP_000450532.1 NZ_CP062888:94515-94742 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp

>AT177145 NZ_CP083257:c1019968-1019723 [Bifidobacterium longum subsp. longum]
ATGAGTATGCAGATTGCCACGCGAGTTGATGACGAGCAGGCTGCGTTGTTTAAGGAGACGACCCGACAGCTGGGTACCAC
CCCGGCCGATGCCCTGCGTATGTTCATCAGCGCGTTCAATGATTACCGTGGGTTCCCCTATGAGGTGCGTTTGCCACGAA
ATGACGTGGAGCCGTTTGCGTCCGAGCGGGACGCTACTGAGTATGCCAGTCGTCTCGCCTTGAGGATGTCCGATGAAACG
AGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References