262261

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4349596..4350410 Replicon chromosome
Accession NZ_CP109874
Organism Escherichia coli strain EC488

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag NQ150_RS20935 Protein ID WP_001054376.1
Coordinates 4349596..4349853 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag NQ150_RS20940 Protein ID WP_001309181.1
Coordinates 4349865..4350410 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ150_RS20910 (4344856) 4344856..4345836 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
NQ150_RS20915 (4345946) 4345946..4346151 + 206 Protein_4096 HNH endonuclease -
NQ150_RS20920 (4346451) 4346451..4347431 - 981 WP_000019400.1 IS5-like element IS5 family transposase -
NQ150_RS20925 (4347618) 4347618..4348858 - 1241 Protein_4098 helicase YjhR -
NQ150_RS20930 (4348974) 4348974..4349105 + 132 WP_001309182.1 hypothetical protein -
NQ150_RS20935 (4349596) 4349596..4349853 + 258 WP_001054376.1 YjhX family toxin Toxin
NQ150_RS20940 (4349865) 4349865..4350410 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
NQ150_RS20945 (4350466) 4350466..4351212 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
NQ150_RS20950 (4351381) 4351381..4351599 + 219 Protein_4103 hypothetical protein -
NQ150_RS20955 (4351637) 4351637..4351753 + 117 Protein_4104 VOC family protein -
NQ150_RS20960 (4351998) 4351998..4353119 + 1122 WP_000010829.1 M42 family metallopeptidase -
NQ150_RS20965 (4353116) 4353116..4353394 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
NQ150_RS20970 (4353406) 4353406..4354719 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4340891..4350410 9519
flank IS/Tn - - 4346451..4347431 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T262261 WP_001054376.1 NZ_CP109874:4349596-4349853 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT262261 WP_001309181.1 NZ_CP109874:4349865-4350410 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References