Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 94520..95145 Replicon plasmid unnamednovel_0
Accession NZ_CP062820
Organism Escherichia coli strain Res13-Sevr-PER06-05-b-A

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IMQ58_RS24600 Protein ID WP_000911317.1
Coordinates 94747..95145 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag IMQ58_RS24595 Protein ID WP_000450532.1
Coordinates 94520..94747 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ58_RS24590 89919..94438 - 4520 Protein_101 conjugative transfer relaxase/helicase TraI -
IMQ58_RS24595 94520..94747 + 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin
IMQ58_RS24600 94747..95145 + 399 WP_000911317.1 tRNA(fMet)-specific endonuclease VapC Toxin
IMQ58_RS24605 95154..97307 - 2154 WP_195686652.1 type IV conjugative transfer system coupling protein TraD -
IMQ58_RS24610 97559..98290 - 732 WP_000850430.1 complement resistance protein TraT -
IMQ58_RS24615 98322..98632 - 311 Protein_106 entry exclusion protein -
IMQ58_RS24620 98665..99681 + 1017 WP_001322394.1 IS5-like element IS5 family transposase -
IMQ58_RS24625 99829..100011 - 183 Protein_108 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..141259 141259
flank IS/Tn - - 98701..99681 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14857.14 Da        Isoelectric Point: 8.5264

>T176697 WP_000911317.1 NZ_CP062820:94747-95145 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

>T176697 NZ_CP082909:c2539833-2539531 [Endozoicomonas sp. 4G]
ATGCCCCCAAACAAGCAGTACTTGTTCAAGCCTCGTGCGCAGCAAGATTTGGAAGACATATATGACTATTCCGCTAGTGA
GTTTGGAGAAGAGCAGGCAGATCTGTATATCCGAAATCTTTTTGATACCTTTCAGCGACTGGCGGAAACGCCGGGCTTTG
CCCGCTACCGGGATGACATCAGAAAAGGACTCAAATCTTACCCTGTGAAGGCTCATATCGTTTTTTTCAGAAAAATGGAG
AATGGCGTATTAATTGTCAGGGTGCTTCACCAGTCAATGGATTTTCAATCAAAAAAATACTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT176697 WP_000450532.1 NZ_CP062820:94520-94747 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp

>AT176697 NZ_CP082909:c2540081-2539839 [Endozoicomonas sp. 4G]
ATGGCTCGAACATTAACCATCAGCCTTGGAGACGAACTTCAGGGCTATGCTCAACAGCTGGTCGATTCCGGTGCGTACTC
ATCCGTCAGTGAAGTGGTTCGCGAGGCGTTAAGAAACCTGAGAGAGCAGAAAGCTTCCTCAAACCTGGAACAATTAAGGG
CAATGATTGACGAAGGTGACAACAGCGGTGAACCGGTTGATCTTAAAGTTGAAAAGTTTCTTGCCCAAATGAAAAAACGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References