Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4359594..4360408 Replicon chromosome
Accession NZ_CP058574
Organism Escherichia coli strain EC1

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag HYH05_RS21035 Protein ID WP_001054376.1
Coordinates 4359594..4359851 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag HYH05_RS21040 Protein ID WP_001309181.1
Coordinates 4359863..4360408 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYH05_RS21015 4354854..4355834 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
HYH05_RS21020 4356449..4357465 - 1017 WP_001322394.1 IS5-like element IS5 family transposase -
HYH05_RS21025 4357616..4358602 - 987 WP_001323209.1 hypothetical protein -
HYH05_RS21030 4358972..4359217 + 246 Protein_4118 GNAT family N-acetyltransferase -
HYH05_RS21035 4359594..4359851 + 258 WP_001054376.1 hypothetical protein Toxin
HYH05_RS21040 4359863..4360408 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
HYH05_RS21045 4360464..4361210 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
HYH05_RS21050 4361379..4361597 + 219 Protein_4122 hypothetical protein -
HYH05_RS21055 4361996..4363117 + 1122 WP_000010829.1 M42 family metallopeptidase -
HYH05_RS21060 4363114..4363392 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
HYH05_RS21065 4363404..4364717 + 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4356449..4357429 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T166862 WP_001054376.1 NZ_CP058574:4359594-4359851 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T166862 NZ_CP074528:c5368088-5367705 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT166862 WP_001309181.1 NZ_CP058574:4359863-4360408 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT166862 NZ_CP074528:c5368330-5368088 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References