Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 30160..30577 Replicon plasmid pEcoFMU07332d
Accession NZ_CP017848
Organism Escherichia coli strain FMU073332

Toxin (Protein)


Gene name hok Uniprot ID -
Locus tag BLJ80_RS27150 Protein ID WP_072328073.1
Coordinates 30160..30318 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name srnC
Locus tag -
Coordinates 30383..30577 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BLJ80_RS27105 25958..26341 - 384 WP_000124827.1 relaxosome protein TraM -
BLJ80_RS27110 26664..27266 + 603 WP_013188482.1 transglycosylase SLT domain-containing protein -
BLJ80_RS27115 27562..28383 - 822 WP_001393327.1 DUF945 domain-containing protein -
BLJ80_RS27120 28500..28787 - 288 WP_000107522.1 hypothetical protein -
BLJ80_RS27130 28943..29245 - 303 WP_001272235.1 hypothetical protein -
BLJ80_RS29880 29562..29922 + 361 Protein_44 hypothetical protein -
BLJ80_RS27150 30160..30318 - 159 WP_072328073.1 type I toxin-antitoxin system Hok family toxin Toxin
- 30383..30577 - 195 NuclAT_0 - Antitoxin
- 30383..30577 - 195 NuclAT_0 - Antitoxin
- 30383..30577 - 195 NuclAT_0 - Antitoxin
- 30383..30577 - 195 NuclAT_0 - Antitoxin
BLJ80_RS27160 30589..31308 - 720 WP_001276221.1 plasmid SOS inhibition protein A -
BLJ80_RS27165 31305..31739 - 435 WP_000845954.1 conjugation system SOS inhibitor PsiB -
BLJ80_RS29885 31794..33761 - 1968 Protein_48 ParB/RepB/Spo0J family partition protein -
BLJ80_RS27180 33836..34192 - 357 Protein_49 IS3 family transposase -
BLJ80_RS27190 34257..35408 + 1152 WP_001254933.1 IS30-like element IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - eltB / eltA / etpA / etpB / cs3 1..137665 137665
flank IS/Tn - - 24687..25667 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(8-48)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 6070.26 Da        Isoelectric Point: 9.2584

>T68214 WP_072328073.1 NZ_CP017848:c30318-30160 [Escherichia coli]
MKLPRSSLVWCVLTVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Download         Length: 159 bp

>T68214 NZ_CP017848:c30318-30160 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGACCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 195 bp

>AT68214 NZ_CP017848:c30577-30383 [Escherichia coli]
TCACGCGGATTTCCCGTAGCCTGAATGAGCGTATTCTTTTCAGGAAAAGTGAATGTGGCCAGCGCGCAGGGATATGGGCT
ATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACAGTGTTGTGTGGCAGAAGGACAAA
AGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References