192469

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 2629212..2630026 Replicon chromosome
Accession NZ_CP069980
Organism Escherichia coli strain FDAARGOS_1291

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag I6K21_RS12230 Protein ID WP_001054376.1
Coordinates 2629769..2630026 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag I6K21_RS12225 Protein ID WP_001309181.1
Coordinates 2629212..2629757 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K21_RS12195 (2624903) 2624903..2626216 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
I6K21_RS12200 (2626228) 2626228..2626506 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
I6K21_RS12205 (2626503) 2626503..2627624 - 1122 WP_000010829.1 M42 family metallopeptidase -
I6K21_RS12210 (2627869) 2627869..2627985 - 117 Protein_2400 VOC family protein -
I6K21_RS12215 (2628023) 2628023..2628241 - 219 Protein_2401 hypothetical protein -
I6K21_RS12220 (2628410) 2628410..2629156 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
I6K21_RS12225 (2629212) 2629212..2629757 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
I6K21_RS12230 (2629769) 2629769..2630026 - 258 WP_001054376.1 YjhX family toxin Toxin
I6K21_RS25600 (2630517) 2630517..2630648 - 132 WP_001309182.1 hypothetical protein -
I6K21_RS12240 (2630764) 2630764..2632004 + 1241 Protein_2406 helicase YjhR -
I6K21_RS12245 (2632191) 2632191..2633171 + 981 WP_000019400.1 IS5-like element IS5 family transposase -
I6K21_RS25605 (2633471) 2633471..2633676 - 206 Protein_2408 HNH endonuclease -
I6K21_RS12250 (2633786) 2633786..2634766 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2632191..2633171 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T192469 WP_001054376.1 NZ_CP069980:c2630026-2629769 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T192469 NZ_CP092417:c3366793-3366593 [Endozoicomonas sp. SCSIO W0465]
ATGATTTTCATTGAAACAAGCAAATTTACCAAGCTGCTTTCTGATTATTTATCGGATGATGAATACAGAATGTTGCAATG
GCATCTACAGGAAAAGCCGGACTCTGGTGATATTGTCCGTGGTAGCGGCGGTGTTCGAAAAGTGCGTTGGGCTCCTGAAG
GCAAAGGTAAAAGCAGTGGTGTTCGAGTAATTTACCACTGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT192469 WP_001309181.1 NZ_CP069980:c2629757-2629212 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT192469 NZ_CP092417:c3366489-3366202 [Endozoicomonas sp. SCSIO W0465]
ATGAGTAAAAGAGATATAGGTCAAGAAATTCTTGATGGCATTGAGGAGATTAAAGCTTTCAAGTCCGGTGAAGGTAAGCT
TAAAACTTCTATCCTTTCCGATCCGTCACCTGCTAAAGAAATCAGGAAAAAGTTAAAGCTTTCGCAGTCTGCTTTTGCTG
GCCTTATGGGTGTCAGCATAAGAACCATACAAGATTGGGAGCAAGGTCGCCGAAGCCCCCAAGGCCCAGCAAAAGCACTG
CTAAGAATCGCAGAGCAATGCCCTGAAGTGTTTCAAGAGTTGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References