242032

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4330299..4331113 Replicon chromosome
Accession NZ_CP095448
Organism Escherichia coli strain LS45

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag MWN28_RS21015 Protein ID WP_001054376.1
Coordinates 4330299..4330556 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag MWN28_RS21020 Protein ID WP_001309181.1
Coordinates 4330568..4331113 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWN28_RS20990 (4325559) 4325559..4326539 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
MWN28_RS20995 (4326649) 4326649..4326854 + 206 Protein_4123 HNH endonuclease -
MWN28_RS21000 (4327154) 4327154..4328134 - 981 WP_000019400.1 IS5-like element IS5 family transposase -
MWN28_RS21005 (4328321) 4328321..4329561 - 1241 Protein_4125 helicase YjhR -
MWN28_RS21010 (4329677) 4329677..4329808 + 132 WP_001309182.1 hypothetical protein -
MWN28_RS21015 (4330299) 4330299..4330556 + 258 WP_001054376.1 YjhX family toxin Toxin
MWN28_RS21020 (4330568) 4330568..4331113 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
MWN28_RS21025 (4331169) 4331169..4331915 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
MWN28_RS21030 (4332084) 4332084..4332302 + 219 Protein_4130 hypothetical protein -
MWN28_RS21035 (4332340) 4332340..4332456 + 117 Protein_4131 VOC family protein -
MWN28_RS21040 (4332701) 4332701..4333822 + 1122 WP_000010829.1 M42 family metallopeptidase -
MWN28_RS21045 (4333819) 4333819..4334097 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
MWN28_RS21050 (4334109) 4334109..4335422 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 4318885..4339337 20452
flank IS/Tn - - 4327154..4328134 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T242032 WP_001054376.1 NZ_CP095448:4330299-4330556 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T242032 NZ_OV024757:1169864-1170217 [Deinococcus radiodurans]
ATGGTAAGCGATTATGTCCCGGACGCTGGGCATCTGGTGTGGCTCAACTTCACACCTCAGGCAGGGCATGAACAGGGGGG
ACGGCGACCGGCGCTGGTGCTTTCGCCTGCCGCTTATAACGGCGTCACTGGACTGATGCAGGCGTGTCCGGTGACCAGCC
GCGCCAAGGGGTATCCGTTTGAAGTGACGCTCCCTGCTCACCTTGGAGTCAGCGGCGTGGTGCTGGCCGACCATTGCCGC
AGCCTCGACTGGCGCAGTCGCCGGGCCGAACAACTTGCGGAGGCGCCGGCGGACGTCCTGGCCGAAGTCCGTGGCAAGTT
GGGCAGCTTGCTGGGCATGTCCGAGAAGGCATGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT242032 WP_001309181.1 NZ_CP095448:4330568-4331113 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT242032 NZ_OV024757:1169628-1169870 [Deinococcus radiodurans]
ATGACGAGTCAAATTCAGAAATGGGGCAACAGCCTCGCGCTCCGCATTCCCAAAGCTCTGGCGCAGCAGGTGGGACTGAC
GCAGAGTTCAGAAGTGGAGCTGCTTCTTCAGGACGGTCAGATTGTCATCCGGCCAGTTCCTGCTCGGCAGTACGATCTCG
CCGCGCTGCTGGCCGAAATGACACCTGAAAATCTGCATGGGGAAACAGACTGGGGCGCACTGGAAGGACGCGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References