106394

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 619275..619999 Replicon chromosome
Accession NZ_CP029687
Organism Escherichia coli strain E706

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag DMI84_RS03315 Protein ID WP_063120790.1
Coordinates 619275..619664 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag DMI84_RS03320 Protein ID WP_001307405.1
Coordinates 619664..619999 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DMI84_RS03295 615522..616382 + 861 WP_000809262.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
DMI84_RS03300 616425..617516 - 1092 WP_000816992.1 fimbrial protein -
DMI84_RS03305 617527..617985 - 459 Protein_599 fimbria/pilus outer membrane usher protein -
DMI84_RS03310 618076..619304 + 1229 WP_116315299.1 IS3 family transposase -
DMI84_RS03315 619275..619664 - 390 WP_063120790.1 type II toxin-antitoxin system YhaV family toxin Toxin
DMI84_RS03320 619664..619999 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
DMI84_RS03325 620148..621719 - 1572 WP_001273753.1 galactarate dehydratase -
DMI84_RS03330 622094..623428 + 1335 WP_118014614.1 galactarate/glucarate/glycerate transporter GarP -
DMI84_RS03335 623444..624214 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 618076..630874 12798


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-117)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14861.00 Da        Isoelectric Point: 9.2986

>T106394 WP_063120790.1 NZ_CP029687:c619664-619275 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLDLPLYFQTPVIT

Download         Length: 390 bp

>T106394 NZ_CP029687:c619664-619275 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGGATTTGCCCCTATATTTCCAGACACCTGTTATCACTTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT106394 WP_001307405.1 NZ_CP029687:c619999-619664 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT106394 NZ_CP029687:c619999-619664 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References