296058

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 606262..607061 Replicon chromosome
Accession NZ_OW968288
Organism Escherichia coli isolate 10

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag LQ134_RS02950 Protein ID WP_000347275.1
Coordinates 606262..606726 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag LQ134_RS02955 Protein ID WP_001307405.1
Coordinates 606726..607061 (-) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ134_RS02920 (601263) 601263..601697 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
LQ134_RS02925 (601715) 601715..602593 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
LQ134_RS02930 (602583) 602583..603362 - 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
LQ134_RS02935 (603373) 603373..603846 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
LQ134_RS02940 (603869) 603869..605149 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
LQ134_RS02945 (605398) 605398..606207 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
LQ134_RS02950 (606262) 606262..606726 - 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
LQ134_RS02955 (606726) 606726..607061 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
LQ134_RS02960 (607210) 607210..608781 - 1572 WP_001273752.1 galactarate dehydratase -
LQ134_RS02965 (609156) 609156..610490 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
LQ134_RS02970 (610506) 610506..611276 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 606262..617936 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T296058 WP_000347275.1 NZ_OW968288:c606726-606262 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp


Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT296058 WP_001307405.1 NZ_OW968288:c607061-606726 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References