262654

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3374106..3374905 Replicon chromosome
Accession NZ_CP110014
Organism Escherichia coli strain HE_100-10

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag OLR77_RS16620 Protein ID WP_000347273.1
Coordinates 3374441..3374905 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag OLR77_RS16615 Protein ID WP_001307405.1
Coordinates 3374106..3374441 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR77_RS16600 (3369891) 3369891..3370661 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
OLR77_RS16605 (3370677) 3370677..3372011 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
OLR77_RS16610 (3372386) 3372386..3373957 + 1572 WP_001273753.1 galactarate dehydratase -
OLR77_RS16615 (3374106) 3374106..3374441 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
OLR77_RS16620 (3374441) 3374441..3374905 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
OLR77_RS16625 (3374960) 3374960..3375769 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
OLR77_RS16630 (3376018) 3376018..3377298 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
OLR77_RS16635 (3377321) 3377321..3377794 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
OLR77_RS16640 (3377805) 3377805..3378176 + 372 Protein_3251 PTS sugar transporter subunit IIC -
OLR77_RS16645 (3378172) 3378172..3378729 + 558 Protein_3252 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3364958..3374905 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T262654 WP_000347273.1 NZ_CP110014:3374441-3374905 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT262654 WP_001307405.1 NZ_CP110014:3374106-3374441 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References