88583

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1301297..1302096 Replicon chromosome
Accession NZ_CP024815
Organism Escherichia coli strain CREC-629

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag CU080_RS06645 Protein ID WP_100183819.1
Coordinates 1301297..1301761 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag CU080_RS06650 Protein ID WP_001307405.1
Coordinates 1301761..1302096 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CU080_RS06610 1296298..1296732 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
CU080_RS06615 1296750..1297628 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
CU080_RS06620 1297618..1298397 - 780 WP_000406209.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
CU080_RS06625 1298408..1298881 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
CU080_RS06630 1298904..1300184 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
CU080_RS06640 1300433..1301242 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
CU080_RS06645 1301297..1301761 - 465 WP_100183819.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
CU080_RS06650 1301761..1302096 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
CU080_RS06655 1302245..1303816 - 1572 WP_001273752.1 galactarate dehydratase -
CU080_RS06660 1304191..1305525 + 1335 WP_100183820.1 galactarate/glucarate/glycerate transporter GarP -
CU080_RS06665 1305541..1306311 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1301297..1312971 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17790.27 Da        Isoelectric Point: 9.8492

>T88583 WP_100183819.1 NZ_CP024815:c1301761-1301297 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T88583 NZ_CP024815:c1301761-1301297 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT88583 WP_001307405.1 NZ_CP024815:c1302096-1301761 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT88583 NZ_CP024815:c1302096-1301761 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References