268074

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4144960..4145759 Replicon chromosome
Accession NZ_CP116115
Organism Escherichia coli strain DETEC-P793

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag PIC92_RS20310 Protein ID WP_000347275.1
Coordinates 4145295..4145759 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag PIC92_RS20305 Protein ID WP_001307405.1
Coordinates 4144960..4145295 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC92_RS20290 (4140745) 4140745..4141515 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
PIC92_RS20295 (4141531) 4141531..4142865 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
PIC92_RS20300 (4143240) 4143240..4144811 + 1572 WP_001273752.1 galactarate dehydratase -
PIC92_RS20305 (4144960) 4144960..4145295 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PIC92_RS20310 (4145295) 4145295..4145759 + 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PIC92_RS20315 (4145814) 4145814..4146623 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
PIC92_RS20320 (4146872) 4146872..4148152 + 1281 WP_000681933.1 tagatose-bisphosphate aldolase subunit KbaZ -
PIC92_RS20325 (4148175) 4148175..4148648 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
PIC92_RS20330 (4148659) 4148659..4149438 + 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
PIC92_RS20335 (4149428) 4149428..4150306 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PIC92_RS20340 (4150324) 4150324..4150758 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4135812..4145759 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T268074 WP_000347275.1 NZ_CP116115:4145295-4145759 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT268074 WP_001307405.1 NZ_CP116115:4144960-4145295 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References