264695

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2026502..2027301 Replicon chromosome
Accession NZ_CP110996
Organism Escherichia coli strain XYEH3783

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag ORI30_RS09735 Protein ID WP_000347275.1
Coordinates 2026837..2027301 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag ORI30_RS09730 Protein ID WP_001307405.1
Coordinates 2026502..2026837 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI30_RS09715 (2022287) 2022287..2023057 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
ORI30_RS09720 (2023073) 2023073..2024407 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
ORI30_RS09725 (2024782) 2024782..2026353 + 1572 WP_001273752.1 galactarate dehydratase -
ORI30_RS09730 (2026502) 2026502..2026837 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
ORI30_RS09735 (2026837) 2026837..2027301 + 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
ORI30_RS09740 (2027356) 2027356..2028165 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
ORI30_RS09745 (2028414) 2028414..2029694 + 1281 WP_000681933.1 tagatose-bisphosphate aldolase subunit KbaZ -
ORI30_RS09750 (2029717) 2029717..2030190 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
ORI30_RS09755 (2030201) 2030201..2030980 + 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
ORI30_RS09760 (2030970) 2030970..2031848 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
ORI30_RS09765 (2031866) 2031866..2032300 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2017354..2027301 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T264695 WP_000347275.1 NZ_CP110996:2026837-2027301 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT264695 WP_001307405.1 NZ_CP110996:2026502-2026837 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References