142439

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1656009..1656808 Replicon chromosome
Accession NZ_CP045741
Organism Escherichia coli strain DH5alpha

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag GHR40_RS07905 Protein ID WP_000347273.1
Coordinates 1656009..1656473 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag GHR40_RS07910 Protein ID WP_001307405.1
Coordinates 1656473..1656808 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHR40_RS07880 1652185..1652742 - 558 Protein_1519 amidohydrolase family protein -
GHR40_RS07885 1652738..1653109 - 372 Protein_1520 PTS sugar transporter subunit IIC -
GHR40_RS07890 1653120..1653593 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
GHR40_RS07895 1653616..1654896 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
GHR40_RS07900 1655145..1655954 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
GHR40_RS07905 1656009..1656473 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
GHR40_RS07910 1656473..1656808 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
GHR40_RS07915 1656957..1658528 - 1572 WP_001273747.1 galactarate dehydratase -
GHR40_RS07920 1658903..1660237 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
GHR40_RS07925 1660253..1661023 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1656009..1667666 11657


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T142439 WP_000347273.1 NZ_CP045741:c1656473-1656009 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T142439 NZ_CP060693:c2104309-2103977 [Aliarcobacter cryaerophilus]
ATGGTAAATTATATTCCAAGCAAAGGTGATATTGTAACATTAGATTTTGATCCACAAAAGGGACACGAGCAAAAAGGAAG
AAGACCAGCTTTGATTTTAAGTAATAAAACTTTTAATAAAGCTTTAGGTTTAGCATTTGCTTGTCCAATTACAAGTACAA
AAAGGGATTTCCCTTTTCATGTAAAAATCCAAAGCCAAAAAATTTCTGGTTTTATTATGGCTGAACAGTTAAAATCTATT
GATTATGACTCAAGAAATATAAAATTTGTTGAAAAAGTAGATAAGCAGATACTAGAAGAGATTGAAGCTATAGTAGATGC
AATTATAAAGTAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT142439 WP_001307405.1 NZ_CP045741:c1656808-1656473 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT142439 NZ_CP060693:c2104545-2104303 [Aliarcobacter cryaerophilus]
ATGACAGTAACTATTTCAAAATGGGGAAACTCTCAAGGCTTTAGAGTTCCAAAAGATATATTAGATAAGTTAAATTTAGC
AGTTGGTGATTTGGTAAATATCTCTCAAAAAGATAATAAATTAATAATAGAACCAGTAAAAAAAGAGAAAAAATATAGTA
TAGATGAGCTTGTGAATAATCTACCAAAAGGTTACAAAGCTAGTGAAGAGTTTAGCTCTAAGAGTGGTTCTGAAATATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References