36994

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2796251..2797050 Replicon chromosome
Accession NZ_AP023230
Organism Escherichia coli strain YJ4

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag HXS62_RS13390 Protein ID WP_000347275.1
Coordinates 2796251..2796715 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag HXS62_RS13395 Protein ID WP_001307405.1
Coordinates 2796715..2797050 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXS62_RS13360 2791252..2791686 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
HXS62_RS13365 2791704..2792582 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HXS62_RS13370 2792572..2793351 - 780 WP_000406209.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
HXS62_RS13375 2793362..2793835 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
HXS62_RS13380 2793858..2795138 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
HXS62_RS13385 2795387..2796196 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
HXS62_RS13390 2796251..2796715 - 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
HXS62_RS13395 2796715..2797050 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
HXS62_RS13400 2797199..2798770 - 1572 WP_001273752.1 galactarate dehydratase -
HXS62_RS13405 2799145..2800479 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
HXS62_RS13410 2800495..2801265 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2796251..2807925 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T36994 WP_000347275.1 NZ_AP023230:c2796715-2796251 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T36994 NZ_AP023230:c2796715-2796251 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT36994 WP_001307405.1 NZ_AP023230:c2797050-2796715 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT36994 NZ_AP023230:c2797050-2796715 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References