170797

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3261734..3262533 Replicon chromosome
Accession NZ_CP060708
Organism Escherichia coli strain MFDpir

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag H9446_RS15840 Protein ID WP_000347273.1
Coordinates 3262069..3262533 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag H9446_RS15835 Protein ID WP_001307405.1
Coordinates 3261734..3262069 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9446_RS15820 3257519..3258289 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
H9446_RS15825 3258305..3259639 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
H9446_RS15830 3260014..3261585 + 1572 WP_001273753.1 galactarate dehydratase -
H9446_RS15835 3261734..3262069 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
H9446_RS15840 3262069..3262533 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
H9446_RS15845 3262588..3263397 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
H9446_RS15850 3263646..3264926 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
H9446_RS15855 3264949..3265422 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
H9446_RS15860 3265433..3265804 + 372 Protein_3094 PTS sugar transporter subunit IIC -
H9446_RS15865 3265800..3266357 + 558 Protein_3095 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3252586..3262533 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T170797 WP_000347273.1 NZ_CP060708:3262069-3262533 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T170797 NZ_CP077706:c2115690-2115508 [Salmonella enterica subsp. enterica]
ATGAAATATAACGAGTTCAGGCGGTGGCTCATCCAACAGGGTGCAAAGTTCATAAATGCACCGGATGGCGGCAGCCATCA
GCGTGTCATACTGAACGGGAAAGAATCTGTATTTCCCTGCCATGGCGCCAAAGAAATGCCGGAGCCGCTCAGAAAGAAAA
TACTCAAGGATTTGGGGCTTTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT170797 WP_001307405.1 NZ_CP060708:3261734-3262069 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT170797 NZ_CP077706:c2115479-2115045 [Salmonella enterica subsp. enterica]
ATGTTTAACTATGCTGTGAAACCTGAGTATGATCCCGCAACAGAAAGCTGGGTTGTCACATGCCGGGATCTGCCACTATT
TAACTCCGTGAGTTTCAGCATTGACGATGCGCTTCTTGAGGCGGTTGATGGTGCCATCGTTGCACTCTCAATCGAAATCG
ACGCACGCCGTCCAGTCCCCATCGCCAGCCAGCCCGAAGAAGGGGAGTATGTCATTCATCTTCCCGTTCTGGTTGTGATG
AAAGCCGCGCTGCATAATGCAATGATTTCCACAGGGACACGAAAATCCGATCTTGCCCGAACTATGAGGATGAAAGGTCC
CCAGATAGATCGCCTCCTGGATGTTTGCCACTCATCGAAAGTGGAAACAGTAGAACTCGCTCTTCAGCAACTCAACCGGA
CTGTACAGATAAGCGTTGATAACGTTGCGGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References