286604

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 618004..618803 Replicon chromosome
Accession NZ_LR134075
Organism Escherichia coli strain NCTC9084

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag EL019_RS02995 Protein ID WP_000347273.1
Coordinates 618004..618468 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag EL019_RS03000 Protein ID WP_001307405.1
Coordinates 618468..618803 (-) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL019_RS02965 613005..613439 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
EL019_RS02970 613457..614335 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
EL019_RS02975 614325..615104 - 780 WP_000406209.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
EL019_RS02980 615115..615588 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
EL019_RS02985 615611..616891 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
EL019_RS02990 617140..617949 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
EL019_RS02995 618004..618468 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
EL019_RS03000 618468..618803 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
EL019_RS03005 618952..620523 - 1572 WP_001273753.1 galactarate dehydratase -
EL019_RS03010 620898..622232 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
EL019_RS03015 622248..623018 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 618004..629678 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T286604 WP_000347273.1 NZ_LR134075:c618468-618004 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp


Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT286604 WP_001307405.1 NZ_LR134075:c618803-618468 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V0SSH7


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References