Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 623561..624360 Replicon chromosome
Accession NZ_CP122499
Organism Escherichia coli strain W409

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QC809_RS03085 Protein ID WP_000347273.1
Coordinates 623561..624025 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QC809_RS03090 Protein ID WP_001307405.1
Coordinates 624025..624360 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC809_RS03055 (618562) 618562..618996 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QC809_RS03060 (619014) 619014..619892 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QC809_RS03065 (619882) 619882..620661 - 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
QC809_RS03070 (620672) 620672..621145 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
QC809_RS03075 (621168) 621168..622448 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
QC809_RS03080 (622697) 622697..623506 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QC809_RS03085 (623561) 623561..624025 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QC809_RS03090 (624025) 624025..624360 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QC809_RS03095 (624509) 624509..626080 - 1572 WP_063084662.1 galactarate dehydratase -
QC809_RS03100 (626455) 626455..627789 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QC809_RS03105 (627805) 627805..628575 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 623561..636018 12457


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T277044 WP_000347273.1 NZ_CP122499:c624025-623561 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT277044 WP_001307405.1 NZ_CP122499:c624360-624025 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References