137952

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2403406..2404205 Replicon chromosome
Accession NZ_CP043217
Organism Escherichia coli O80:H26 strain EC-107

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag FYA02_RS12140 Protein ID WP_000347273.1
Coordinates 2403741..2404205 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A0K5UM65
Locus tag FYA02_RS12135 Protein ID WP_025670440.1
Coordinates 2403406..2403741 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA02_RS12120 2399191..2399961 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
FYA02_RS12125 2399977..2401311 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
FYA02_RS12130 2401686..2403257 + 1572 WP_032202412.1 galactarate dehydratase -
FYA02_RS12135 2403406..2403741 + 336 WP_025670440.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
FYA02_RS12140 2403741..2404205 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
FYA02_RS12145 2404260..2405069 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
FYA02_RS12150 2405318..2406598 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
FYA02_RS12155 2406621..2407094 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
FYA02_RS12160 2407105..2407884 + 780 WP_032216390.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
FYA02_RS12165 2407874..2408752 + 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
FYA02_RS12170 2408770..2409204 + 435 WP_000948814.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2394258..2404205 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T137952 WP_000347273.1 NZ_CP043217:2403741-2404205 [Escherichia coli O80:H26]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T137952 NZ_CP057150:3571128-3571457 [Citrobacter sp. RHB35-C17]
ATGCAAACCTTATCATCACACCCGACGCAGGCGGCTCAGCCCTGCCTGTCACCCATTGAAATCTGGCAGTGCCTGCTAAC
TCATCTGTTGTCGCAGCACTATGGCCTGACGCTGAATGACACACCGTTCAGTAATGAAACCACCATACGAGAACATATTG
ATGCTGGAGTATCGCTCAGCGATGCGGTGAACTTTCTGGTAGAAAGATACGGGCTTGTCCGTATCGACCGGAAGGGATTT
TCGTGGCAAGAACAAACCCCGTATATTTCCGTAGTGGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCAAAAAACTAA
CGTGAAATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12387.00 Da        Isoelectric Point: 5.1498

>AT137952 WP_025670440.1 NZ_CP043217:2403406-2403741 [Escherichia coli O80:H26]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PRKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT137952 NZ_CP043217:2403406-2403741 [Escherichia coli O80:H26]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCGAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K5UM65

References