277574

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 611122..611921 Replicon chromosome
Accession NZ_CP122660
Organism Escherichia coli strain ETEC4073

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QDY26_RS02985 Protein ID WP_000347273.1
Coordinates 611122..611586 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDY26_RS02990 Protein ID WP_001307405.1
Coordinates 611586..611921 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY26_RS02955 (606123) 606123..606557 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDY26_RS02960 (606575) 606575..607453 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QDY26_RS02965 (607443) 607443..608222 - 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDY26_RS02970 (608233) 608233..608706 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDY26_RS02975 (608729) 608729..610009 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDY26_RS02980 (610258) 610258..611067 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QDY26_RS02985 (611122) 611122..611586 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDY26_RS02990 (611586) 611586..611921 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDY26_RS02995 (612070) 612070..613641 - 1572 WP_001273753.1 galactarate dehydratase -
QDY26_RS03000 (614016) 614016..615350 + 1335 WP_046788587.1 galactarate/glucarate/glycerate transporter GarP -
QDY26_RS03005 (615366) 615366..616136 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 611122..622795 11673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T277574 WP_000347273.1 NZ_CP122660:c611586-611122 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT277574 WP_001307405.1 NZ_CP122660:c611921-611586 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References