292172

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 631073..631872 Replicon chromosome
Accession NZ_LS483297
Organism Escherichia coli strain NCTC11023

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag DQM98_RS03320 Protein ID WP_000347273.1
Coordinates 631073..631537 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID V0TI39
Locus tag DQM98_RS03325 Protein ID WP_021547164.1
Coordinates 631537..631872 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM98_RS03285 626074..626508 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
DQM98_RS03290 626526..627404 - 879 WP_001300474.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
DQM98_RS03295 627394..628173 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
DQM98_RS03300 628184..628657 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
DQM98_RS03305 628680..629960 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
DQM98_RS03315 630209..631018 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
DQM98_RS03320 631073..631537 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
DQM98_RS03325 631537..631872 - 336 WP_021547164.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
DQM98_RS03330 632021..633592 - 1572 WP_001753084.1 galactarate dehydratase -
DQM98_RS03335 633967..635301 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
DQM98_RS03340 635317..636087 + 771 WP_111732345.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 631073..642747 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T292172 WP_000347273.1 NZ_LS483297:c631537-631073 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12309.86 Da        Isoelectric Point: 4.5392

>AT292172 WP_021547164.1 NZ_LS483297:c631872-631537 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDTQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB V0TI39

References