292761

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 604925..605724 Replicon chromosome
Accession NZ_LS992171
Organism Escherichia coli isolate Escherichia coli str. TO73

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag ECTO73_RS02940 Protein ID WP_000347275.1
Coordinates 604925..605389 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag ECTO73_RS02945 Protein ID WP_001307405.1
Coordinates 605389..605724 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO73_RS02910 599926..600360 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
ECTO73_RS02915 600378..601256 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
ECTO73_RS02920 601246..602025 - 780 WP_000406209.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
ECTO73_RS02925 602036..602509 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
ECTO73_RS02930 602532..603812 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
ECTO73_RS02935 604061..604870 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
ECTO73_RS02940 604925..605389 - 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
ECTO73_RS02945 605389..605724 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
ECTO73_RS02950 605873..607444 - 1572 WP_001273752.1 galactarate dehydratase -
ECTO73_RS02955 607819..609153 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
ECTO73_RS02960 609169..609939 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 604925..616599 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T292761 WP_000347275.1 NZ_LS992171:c605389-604925 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT292761 WP_001307405.1 NZ_LS992171:c605724-605389 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References