282847

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 623036..623835 Replicon chromosome
Accession NZ_CP126343
Organism Escherichia coli strain DAX4

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag QN220_RS03045 Protein ID WP_153443454.1
Coordinates 623036..623500 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QN220_RS03050 Protein ID WP_001307405.1
Coordinates 623500..623835 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN220_RS03015 (618037) 618037..618471 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QN220_RS03020 (618489) 618489..619367 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QN220_RS03025 (619357) 619357..620136 - 780 WP_284562154.1 PTS N-acetylgalactosamine transporter subunit IIC -
QN220_RS03030 (620147) 620147..620620 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
QN220_RS03035 (620643) 620643..621923 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
QN220_RS03040 (622172) 622172..622981 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QN220_RS03045 (623036) 623036..623500 - 465 WP_153443454.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QN220_RS03050 (623500) 623500..623835 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QN220_RS03055 (623984) 623984..625555 - 1572 WP_153443453.1 galactarate dehydratase -
QN220_RS03060 (625930) 625930..627264 + 1335 WP_284562155.1 galactarate/glucarate/glycerate transporter GarP -
QN220_RS03065 (627280) 627280..628050 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 623036..634710 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.23 Da        Isoelectric Point: 9.8489

>T282847 WP_153443454.1 NZ_CP126343:c623500-623036 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADRETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT282847 WP_001307405.1 NZ_CP126343:c623835-623500 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References