166806

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 702498..703297 Replicon chromosome
Accession NZ_CP058571
Organism Escherichia coli strain EC2

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag HX136_RS03340 Protein ID WP_179231286.1
Coordinates 702833..703297 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A0N8IST8
Locus tag HX136_RS03335 Protein ID WP_016246345.1
Coordinates 702498..702833 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HX136_RS03320 698283..699053 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
HX136_RS03325 699069..700403 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
HX136_RS03330 700778..702349 + 1572 WP_179231285.1 galactarate dehydratase -
HX136_RS03335 702498..702833 + 336 WP_016246345.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
HX136_RS03340 702833..703297 + 465 WP_179231286.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
HX136_RS03345 703352..704161 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
HX136_RS03350 704410..705690 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
HX136_RS03355 705713..706186 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
HX136_RS03360 706197..706976 + 780 WP_000406209.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
HX136_RS03365 706966..707844 + 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HX136_RS03370 707862..708296 + 435 WP_000948824.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 693350..703297 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17790.27 Da        Isoelectric Point: 9.9815

>T166806 WP_179231286.1 NZ_CP058571:702833-703297 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGRMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T166806 NZ_CP074446:c4534221-4533901 [Klebsiella aerogenes]
ATGAAAACTCTACCTGCAATAAATCCGCAGGCGGCGACGCTATGTCTGTCGCCCGTGGCAGTCTGGCAAAAGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGACTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCTGGAACATATCT
ATGCTGGTATATCTTTGGCCGATGCCGTGAATTTTCTGGTGGAAAAGTATGAGCTGGTTCGTATTGATCGCAGAGGGTTT
AACTGGCGGGAGCAATCACCTTATCTTCAAGTTGTAGATATCCTGCGGGTACGACAAGCTATTGGCAGCTCAAGCAAGTA
A

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12388.97 Da        Isoelectric Point: 4.8616

>AT166806 WP_016246345.1 NZ_CP058571:702498-702833 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPSGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT166806 NZ_CP074446:c4534583-4534242 [Klebsiella aerogenes]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCCAGTGGGGACTGAATCGTAATGTGACGCCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGGCTGCACTATCTGGTTGACCGGGCCAGCATTACCGGTGAATTCAGTAACGCAGAATCTT
TGAAGTTGGATGAAGTATTCCCACATTTTATCAGCAAGATGGAGTCGATGTTGACTACTGGTGAATTGAATCCTCGGCAT
GCCCACTGTTTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGC
CATTTACCCCACTCAGCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0N8IST8

References