151666

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4121994..4122793 Replicon chromosome
Accession NZ_CP049839
Organism Escherichia coli strain UPEC-455U/190220

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag G9W36_RS20000 Protein ID WP_000347275.1
Coordinates 4122329..4122793 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag G9W36_RS19995 Protein ID WP_001307405.1
Coordinates 4121994..4122329 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9W36_RS19980 (4117779) 4117779..4118549 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
G9W36_RS19985 (4118565) 4118565..4119899 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
G9W36_RS19990 (4120274) 4120274..4121845 + 1572 WP_001273752.1 galactarate dehydratase -
G9W36_RS19995 (4121994) 4121994..4122329 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
G9W36_RS20000 (4122329) 4122329..4122793 + 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
G9W36_RS20005 (4122848) 4122848..4123657 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
G9W36_RS20010 (4123906) 4123906..4125186 + 1281 WP_000681933.1 tagatose-bisphosphate aldolase subunit KbaZ -
G9W36_RS20015 (4125209) 4125209..4125682 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
G9W36_RS20020 (4125693) 4125693..4126472 + 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
G9W36_RS20025 (4126462) 4126462..4127340 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
G9W36_RS20030 (4127358) 4127358..4127792 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4112846..4122793 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T151666 WP_000347275.1 NZ_CP049839:4122329-4122793 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T151666 NZ_CP065640:4821793-4822209 [Serratia rubidaea]
ATGAGCCACACCTACATGCTGGACACCTGTATTTGCTCTTACATTATGCGCGAGCAGCCAGCAGCGGCGATCCGGCGTCT
GGAGCAGGCGGTGATGCAACGCCATCGGATCGTGGTGTCGGCCATTACCTATGCCGAAATGCGCTTTGGTGCGATCGGTA
AAAAGGCCTCACCGCGTCATACGCAGCTGGTCGAGGCCTTCTGCAGCCGCCTTGACGCCATTTTGCCGTGGGACCGCGCC
GCGGTGGATGAAACCACGACGCTGAAGGCCGCGTTGGCCGCCGCCGGTACGCCGATCGGGCCCAACGATACCGCAATTGC
CGGCCATGCCATCGCCACTGGCGCCATTCTGGTCACCAATAATGACAAGGAGTTTGCGCGCGTGCCCGGGCTGGCGCTGG
AGGACTGGTCGGCATAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT151666 WP_001307405.1 NZ_CP049839:4121994-4122329 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT151666 NZ_CP065640:4821566-4821796 [Serratia rubidaea]
ATGAGAACAGTATCTGTGTTTAAAAACGGCAATAACCGCGCGATCCGCCTGCCCCGCGATATGGATTTTGCAGGCGTCAA
CGAACTGGAGATCGTCCGTGAAGGCGACACCATCATCCTGAGGCCGGTAAAGCCGAGCTGGGGATCGTTTCTGCTGGAAG
ACAAAGCCGATGCGGACTTTATGACGGAACGTGAAGACATCATTAATGACGAGGGACGCGTCAAACCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References