267914

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4103058..4103857 Replicon chromosome
Accession NZ_CP116094
Organism Escherichia coli strain DETEC-S560

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag PIC78_RS19835 Protein ID WP_000347275.1
Coordinates 4103393..4103857 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag PIC78_RS19830 Protein ID WP_001307405.1
Coordinates 4103058..4103393 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC78_RS19815 (4098843) 4098843..4099613 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
PIC78_RS19820 (4099629) 4099629..4100963 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
PIC78_RS19825 (4101338) 4101338..4102909 + 1572 WP_001273752.1 galactarate dehydratase -
PIC78_RS19830 (4103058) 4103058..4103393 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PIC78_RS19835 (4103393) 4103393..4103857 + 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PIC78_RS19840 (4103912) 4103912..4104721 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
PIC78_RS19845 (4104970) 4104970..4106250 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
PIC78_RS19850 (4106273) 4106273..4106746 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
PIC78_RS19855 (4106757) 4106757..4107536 + 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
PIC78_RS19860 (4107526) 4107526..4108404 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PIC78_RS19865 (4108422) 4108422..4108856 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4092844..4103857 11013


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T267914 WP_000347275.1 NZ_CP116094:4103393-4103857 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT267914 WP_001307405.1 NZ_CP116094:4103058-4103393 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References