268350

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4159755..4160554 Replicon chromosome
Accession NZ_CP116188
Organism Escherichia coli strain DETEC-E223

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag PIC88_RS20365 Protein ID WP_000347273.1
Coordinates 4160090..4160554 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag PIC88_RS20360 Protein ID WP_001307405.1
Coordinates 4159755..4160090 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC88_RS20345 (4155540) 4155540..4156310 - 771 WP_048218026.1 2-dehydro-3-deoxyglucarate aldolase -
PIC88_RS20350 (4156326) 4156326..4157660 - 1335 WP_001723935.1 galactarate/glucarate/glycerate transporter GarP -
PIC88_RS20355 (4158035) 4158035..4159606 + 1572 WP_001723936.1 galactarate dehydratase -
PIC88_RS20360 (4159755) 4159755..4160090 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PIC88_RS20365 (4160090) 4160090..4160554 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PIC88_RS20370 (4160609) 4160609..4161418 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
PIC88_RS20375 (4161667) 4161667..4162947 + 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
PIC88_RS20380 (4162970) 4162970..4163443 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
PIC88_RS20385 (4163454) 4163454..4164233 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
PIC88_RS20390 (4164223) 4164223..4165101 + 879 WP_001300474.1 PTS N-acetylgalactosamine transporter subunit IID -
PIC88_RS20395 (4165119) 4165119..4165553 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4150608..4160554 9946


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T268350 WP_000347273.1 NZ_CP116188:4160090-4160554 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT268350 WP_001307405.1 NZ_CP116188:4159755-4160090 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References