204386

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2391303..2392102 Replicon chromosome
Accession NZ_CP075737
Organism Escherichia coli strain CPF6

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag KKZ13_RS11410 Protein ID WP_000347273.1
Coordinates 2391638..2392102 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag KKZ13_RS11405 Protein ID WP_001307405.1
Coordinates 2391303..2391638 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKZ13_RS11390 (2387088) 2387088..2387858 - 771 WP_001723934.1 2-dehydro-3-deoxyglucarate aldolase -
KKZ13_RS11395 (2387874) 2387874..2389208 - 1335 WP_089075269.1 galactarate/glucarate/glycerate transporter GarP -
KKZ13_RS11400 (2389583) 2389583..2391154 + 1572 WP_001723936.1 galactarate dehydratase -
KKZ13_RS11405 (2391303) 2391303..2391638 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
KKZ13_RS11410 (2391638) 2391638..2392102 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
KKZ13_RS11415 (2392157) 2392157..2392966 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
KKZ13_RS11420 (2393215) 2393215..2394495 + 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
KKZ13_RS11425 (2394518) 2394518..2394991 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
KKZ13_RS11430 (2395002) 2395002..2395781 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
KKZ13_RS11435 (2395771) 2395771..2396649 + 879 WP_001300474.1 PTS N-acetylgalactosamine transporter subunit IID -
KKZ13_RS11440 (2396667) 2396667..2397101 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2382156..2392102 9946


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T204386 WP_000347273.1 NZ_CP075737:2391638-2392102 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T204386 NZ_CP100715:c996592-996065 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT204386 WP_001307405.1 NZ_CP075737:2391303-2391638 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT204386 NZ_CP100715:c996879-996589 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References