166450

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1637410..1638209 Replicon chromosome
Accession NZ_CP058302
Organism Escherichia coli strain AH65

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag HUU85_RS07865 Protein ID WP_000347273.1
Coordinates 1637745..1638209 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag HUU85_RS07860 Protein ID WP_001307405.1
Coordinates 1637410..1637745 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUU85_RS07845 1633195..1633965 - 771 WP_001723934.1 2-dehydro-3-deoxyglucarate aldolase -
HUU85_RS07850 1633981..1635315 - 1335 WP_001723935.1 galactarate/glucarate/glycerate transporter GarP -
HUU85_RS07855 1635690..1637261 + 1572 WP_001723936.1 galactarate dehydratase -
HUU85_RS07860 1637410..1637745 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
HUU85_RS07865 1637745..1638209 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
HUU85_RS07870 1638264..1639073 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
HUU85_RS07875 1639322..1640602 + 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
HUU85_RS07880 1640625..1641098 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
HUU85_RS07885 1641109..1641888 + 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
HUU85_RS07890 1641878..1642756 + 879 WP_001300474.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HUU85_RS07895 1642774..1643208 + 435 WP_000948824.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1628263..1638209 9946


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T166450 WP_000347273.1 NZ_CP058302:1637745-1638209 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T166450 NZ_CP074160:123606-123911 [Enterobacter sp. JBIWA005]
ATGCAGTTCAGGGTTTACACATATAAAAGAGAGAGTCGCTACCGTCTGTTCGTGGATGTGCAGAGTGATATTGTTGATAC
CCCGGGACGGCGAATGGTGATCCCGCTGGCCAGTGCCCGCCTGCTGTCGGACAAGGTCTCCCGCGAACTCTATCCGGTGG
TGCACATCGGGGACGACAGCTACCGGCTGATGACCACTGATATGGCCAGCGTCACCGCAGCCGTTACCGGCGAGGAGGTG
GCCGATCTCAGCCACAGGGAGAATGAGATCAAGAACGCGATTAACCTGATGTTCTGGGGGGTATAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT166450 WP_001307405.1 NZ_CP058302:1637410-1637745 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT166450 NZ_CP074160:123386-123604 [Enterobacter sp. JBIWA005]
ATGAAGCAGCGTATAACTGTCACCATAGACAGCGACAGTTACCGGTTACTGAAATCCGCGGACGTCAATATCTCGGGTCT
GGTGAATACCGCCATGCAGAACGAAGCCCGACGTCTTCGTGCAGAACGCTGGCAGACTGAAAACCAGGAAGGGATGGCTG
AGGTTGCCCGGTTTATCGAAACGAACGGCTCGTTTGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References