Detailed information of TA system    

experimentalExperimentally validated    

Overview


TA module


Type II Classification (family/domain) tacAT/-
Location 4599903..4600708 Replicon chromosome
Accession UFRD01000002
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023

Toxin (Protein)


Gene name TacT3 Uniprot ID -
Locus tag NCTC12023_04871 Protein ID SUI00082.1
Coordinates 4599903..4600430 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID -
Locus tag NCTC12023_04872 Protein ID SUI00083.1
Coordinates 4600427..4600708 (-) Length 94 a.a.

Genomic Context


NCTC12023_04870NCTC12023_04873NCTC12023_04878NCTC12023_04868NCTC12023_04869NCTC12023_04871NCTC12023_04872NCTC12023_04874NCTC12023_04875NCTC12023_04877
Location: 4599654..4599830 (177 bp)
Type: Others
Protein ID: SUI00081.1
Location: 4601406..4601732 (327 bp)
Type: Others
Protein ID: SUI00084.1
Location: 4604018..4604767 (750 bp)
Type: Others
Protein ID: SUI00088.1
Location: 4595203..4597770 (2568 bp)
Type: Others
Protein ID: SUI00079.1
Location: 4598622..4599278 (657 bp)
Type: Others
Protein ID: SUI00080.1
Location: 4599903..4600430 (528 bp)
Type: Toxin
Protein ID: SUI00082.1
Location: 4600427..4600708 (282 bp)
Type: Antitoxin
Protein ID: SUI00083.1
Location: 4602005..4602337 (333 bp)
Type: Others
Protein ID: SUI00085.1
Location: 4602337..4602786 (450 bp)
Type: Others
Protein ID: SUI00086.1
Location: 4603217..4603660 (444 bp)
Type: Others
Protein ID: SUI00087.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NCTC12023_048684595203..4597770-2568SUI00079.1DNA mismatch repair protein MutS-
NCTC12023_048694598622..4599278-657SUI00080.1serine/threonine protein phosphatase-
NCTC12023_048704599654..4599830+177SUI00081.1putative cytoplasmic protein-
NCTC12023_048714599903..4600430-528SUI00082.1acetyltransferaseToxin
NCTC12023_048724600427..4600708-282SUI00083.1ABC transporterAntitoxin
NCTC12023_048734601406..4601732+327SUI00084.1putative cytoplasmic protein-
NCTC12023_048744602005..4602337-333SUI00085.1PrpA and PrpB, metallophosphatase domain protein-
NCTC12023_048754602337..4602786-450SUI00086.1membrane protein-
NCTC12023_048774603217..4603660-444SUI00087.1cell adherance/invasion protein-
NCTC12023_048784604018..4604767+750SUI00088.1invasion protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideGenomic island-invH / invF / invG / invE / invA / invB4599654..461008010426
flankIS/Tn--4599654..4599830176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(4-92)


Sequences


Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T10052 SUI00082.1 UFRD01000002:c4600430-4599903 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T10052 UFRD01000002:c4600430-4599903 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10318.10 Da        Isoelectric Point: 6.3133

>AT10052 SUI00083.1 UFRD01000002:c4600708-4600427 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAPNEK
LLAAAFALPDMKK

Download         Length: 282 bp

>AT10052 UFRD01000002:c4600708-4600427 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGATAGTCCGCGC
TGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTGTTGATGCCG
CCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCGAATGAAAAG
CTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T199Escherichia coli O157:H7 str. EDL933

35.172

90.062

0.317

T10041Mycobacterium tuberculosis H37Rv

33.121

94.578

0.313

Showing 1 to 2 of 2 rows

Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT200Escherichia coli O157:H7 str. EDL933

35.366

93.182

0.33

AT10120Klebsiella pneumoniae subsp. pneumoniae HS11286

36.709

89.773

0.33

Showing 1 to 2 of 2 rows

Multiple sequence alignment    




Structures


Toxin

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Source
ID
Structure
No matching records found


Antitoxin

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Source
ID
Structure
No matching records found

References


(1) Julian A Rycroft et al. (2018) Activity of acetyltransferase toxins involved in Salmonella persister formation during macrophage infection. Nature Communications 9(1):1993. [PubMed:29777131] experimental

(2) Grzegorz J Grabe et al. (2021) Auxiliary interfaces support the evolution of specific toxin-antitoxin pairing. Nature Chemical Biology 17(12):1296-1304. [PubMed:34556858] 3D_structure


experimental experimental literature
3D_structure protein structure literature