294659

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1027669..1028483 Replicon chromosome
Accession NZ_OU015342
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain AUSMDU00007171 isolate AUSMDU00007171

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag KKQ83_RS04940 Protein ID WP_000971655.1
Coordinates 1027669..1028196 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag KKQ83_RS04945 Protein ID WP_000855692.1
Coordinates 1028193..1028483 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKQ83_RS04920 (1022969) 1022969..1025536 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
KKQ83_RS04925 (1025695) 1025695..1026216 + 522 WP_000858988.1 hypothetical protein -
KKQ83_RS04930 (1026388) 1026388..1027044 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
KKQ83_RS04935 (1027391) 1027391..1027596 + 206 Protein_972 IS5/IS1182 family transposase -
KKQ83_RS04940 (1027669) 1027669..1028196 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
KKQ83_RS04945 (1028193) 1028193..1028483 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
KKQ83_RS04950 (1028753) 1028753..1028931 - 179 Protein_975 IS3 family transposase -
KKQ83_RS04955 (1029172) 1029172..1029498 + 327 WP_000393302.1 hypothetical protein -
KKQ83_RS04960 (1029771) 1029771..1030118 - 348 WP_001669174.1 DUF1493 family protein -
KKQ83_RS04965 (1030103) 1030103..1030552 - 450 WP_000381610.1 membrane protein -
KKQ83_RS04970 (1030983) 1030983..1031426 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
KKQ83_RS04975 (1031883) 1031883..1032533 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1027420..1037846 10426
flank IS/Tn - - 1027420..1027596 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T294659 WP_000971655.1 NZ_OU015342:c1028196-1027669 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT294659 WP_000855692.1 NZ_OU015342:c1028483-1028193 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A625WHV3

References