25955

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/-
Location 3069908..3070722 Replicon
Accession NC_016810
Organism Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag SL1344_RS15035 Protein ID WP_000971655.1
Coordinates 3070195..3070722 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag SL1344_RS15030 Protein ID WP_000855692.1
Coordinates 3069908..3070198 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SL1344_RS15005 (SL1344_2878) 3065858..3066508 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
SL1344_RS15010 (SL1344_2879) 3066965..3067408 + 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
SL1344_RS15015 (SL1344_2880) 3067839..3068288 + 450 WP_000381610.1 membrane protein -
SL1344_RS15020 (SL1344_2881) 3068273..3068620 + 348 WP_001669174.1 DUF1493 family protein -
SL1344_RS15025 (SL1344_2882) 3068893..3069219 - 327 WP_000393302.1 hypothetical protein -
SL1344_RS25825 3069460..3069638 + 179 Protein_2960 IS3 family transposase -
SL1344_RS15030 (SL1344_2884) 3069908..3070198 + 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
SL1344_RS15035 (SL1344_2885) 3070195..3070722 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
SL1344_RS26770 (SL1344_2885A) 3070795..3071000 - 206 Protein_2963 IS5/IS1182 family transposase -
SL1344_RS15045 (SL1344_2886) 3071347..3072003 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
SL1344_RS15050 (SL1344_2887) 3072175..3072696 - 522 WP_000858988.1 hypothetical protein -
SL1344_RS15055 (SL1344_2888) 3072855..3075422 + 2568 WP_001005807.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3070795..3070971 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T25955 WP_000971655.1 NC_016810:3070195-3070722 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T25955 NC_016810:3070195-3070722 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT25955 WP_000855692.1 NC_016810:3069908-3070198 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT25955 NC_016810:3069908-3070198 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References