Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 995938..996752 Replicon chromosome
Accession NZ_CP091542
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S58L2

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag L5Z53_RS04765 Protein ID WP_000971655.1
Coordinates 995938..996465 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag L5Z53_RS04770 Protein ID WP_000855692.1
Coordinates 996462..996752 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5Z53_RS04745 (991238) 991238..993805 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
L5Z53_RS04750 (993964) 993964..994485 + 522 WP_000858988.1 hypothetical protein -
L5Z53_RS04755 (994657) 994657..995313 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
L5Z53_RS04760 (995660) 995660..995865 + 206 Protein_933 IS5/IS1182 family transposase -
L5Z53_RS04765 (995938) 995938..996465 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
L5Z53_RS04770 (996462) 996462..996752 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
L5Z53_RS04775 (997022) 997022..997200 - 179 Protein_936 IS3 family transposase -
L5Z53_RS04780 (997441) 997441..997767 + 327 WP_000393302.1 hypothetical protein -
L5Z53_RS04785 (998040) 998040..998387 - 348 WP_001669174.1 DUF1493 family protein -
L5Z53_RS04790 (998372) 998372..998821 - 450 WP_000381610.1 membrane protein -
L5Z53_RS04795 (999252) 999252..999695 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
L5Z53_RS04800 (1000152) 1000152..1000802 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 995689..1006115 10426
flank IS/Tn - - 995689..995865 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T233601 WP_000971655.1 NZ_CP091542:c996465-995938 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T233601 NZ_HG994851:2784915-2785022 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT233601 WP_000855692.1 NZ_CP091542:c996752-996462 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT233601 NZ_HG994851:c2784862-2784801 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References