26055

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/-
Location 3067569..3068383 Replicon
Accession NC_016856
Organism Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag STM14_RS15565 Protein ID WP_000971655.1
Coordinates 3067856..3068383 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag STM14_RS15560 Protein ID WP_000855692.1
Coordinates 3067569..3067859 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STM14_RS15535 (STM14_3498) 3063519..3064169 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
STM14_RS15540 (STM14_3499) 3064626..3065069 + 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
STM14_RS15545 (STM14_3500) 3065500..3065949 + 450 WP_000381610.1 membrane protein -
STM14_RS15550 (STM14_3501) 3065934..3066281 + 348 WP_001669174.1 DUF1493 family protein -
STM14_RS15555 (STM14_3503) 3066554..3066880 - 327 WP_000393302.1 hypothetical protein -
STM14_RS25305 3067121..3067299 + 179 Protein_2952 IS3 family transposase -
STM14_RS15560 (STM14_3505) 3067569..3067859 + 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
STM14_RS15565 (STM14_3506) 3067856..3068383 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
STM14_RS26125 (STM14_3507) 3068456..3068661 - 206 Protein_2955 IS5/IS1182 family transposase -
STM14_RS15575 (STM14_3509) 3069008..3069664 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
STM14_RS15580 (STM14_3510) 3069836..3070357 - 522 WP_000858988.1 hypothetical protein -
STM14_RS15585 (STM14_3511) 3070516..3073083 + 2568 WP_001005807.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3068456..3068632 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T26055 WP_000971655.1 NC_016856:3067856-3068383 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T26055 NC_016856:3067856-3068383 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT26055 WP_000855692.1 NC_016856:3067569-3067859 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT26055 NC_016856:3067569-3067859 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References