238515

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1069512..1070326 Replicon chromosome
Accession NZ_CP093405
Organism Salmonella enterica subsp. enterica serovar Agona strain R21.1368

Toxin (Protein)


Gene name TacT3 Uniprot ID B5F3Y4
Locus tag MOP56_RS05240 Protein ID WP_000971656.1
Coordinates 1069512..1070039 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag MOP56_RS05245 Protein ID WP_000855694.1
Coordinates 1070036..1070326 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP56_RS05210 (1065812) 1065812..1066233 + 422 Protein_1025 cytoplasmic protein -
MOP56_RS05215 (1066401) 1066401..1066640 + 240 Protein_1026 hypothetical protein -
MOP56_RS05220 (1066797) 1066797..1067465 + 669 WP_000445914.1 hypothetical protein -
MOP56_RS05225 (1067492) 1067492..1067986 + 495 WP_000424943.1 hypothetical protein -
MOP56_RS05230 (1068231) 1068231..1068887 - 657 WP_000420449.1 protein-serine/threonine phosphatase -
MOP56_RS05235 (1069237) 1069237..1069439 + 203 Protein_1030 IS5/IS1182 family transposase -
MOP56_RS05240 (1069512) 1069512..1070039 - 528 WP_000971656.1 GNAT family N-acetyltransferase Toxin
MOP56_RS05245 (1070036) 1070036..1070326 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
MOP56_RS05250 (1070919) 1070919..1071245 + 327 WP_000393296.1 hypothetical protein -
MOP56_RS05255 (1071518) 1071518..1071865 - 348 WP_001555786.1 DUF1493 family protein -
MOP56_RS05260 (1071850) 1071850..1072299 - 450 WP_000381619.1 hypothetical protein -
MOP56_RS05265 (1072731) 1072731..1073174 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
MOP56_RS05270 (1073630) 1073630..1074280 + 651 WP_001747511.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1069263..1069439 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19156.98 Da        Isoelectric Point: 9.6420

>T238515 WP_000971656.1 NZ_CP093405:c1070039-1069512 [Salmonella enterica subsp. enterica serovar Agona]
MMFTDWHEAAIGKTHNRMNFDCGNADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHSFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLDRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T238515 NZ_LR890375:53790-54272 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT238515 WP_000855694.1 NZ_CP093405:c1070326-1070036 [Salmonella enterica subsp. enterica serovar Agona]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT238515 NZ_LR890375:53536-53802 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3J3UPI2

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References