Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 997715..998529 Replicon chromosome
Accession NZ_CP117404
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM085

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag PQQ07_RS04775 Protein ID WP_000971655.1
Coordinates 997715..998242 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag PQQ07_RS04780 Protein ID WP_000855692.1
Coordinates 998239..998529 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ07_RS04755 (993015) 993015..995582 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
PQQ07_RS04760 (995741) 995741..996262 + 522 WP_024159753.1 hypothetical protein -
PQQ07_RS04765 (996434) 996434..997090 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
PQQ07_RS04770 (997437) 997437..997642 + 206 Protein_935 IS5/IS1182 family transposase -
PQQ07_RS04775 (997715) 997715..998242 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
PQQ07_RS04780 (998239) 998239..998529 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
PQQ07_RS04785 (998799) 998799..998974 - 176 Protein_938 IS3 family transposase -
PQQ07_RS04790 (999215) 999215..999541 + 327 WP_000393302.1 hypothetical protein -
PQQ07_RS04795 (999814) 999814..1000161 - 348 WP_001669174.1 DUF1493 family protein -
PQQ07_RS04800 (1000146) 1000146..1000595 - 450 WP_000381610.1 membrane protein -
PQQ07_RS04805 (1001026) 1001026..1001469 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PQQ07_RS04810 (1001926) 1001926..1002576 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 997466..1007889 10423
flank IS/Tn - - 997466..997642 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T271195 WP_000971655.1 NZ_CP117404:c998242-997715 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT271195 WP_000855692.1 NZ_CP117404:c998529-998239 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References