222426

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4187352..4188166 Replicon chromosome
Accession NZ_CP085987
Organism Salmonella enterica strain SZL 38

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LKX03_RS21150 Protein ID WP_000971655.1
Coordinates 4187639..4188166 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag LKX03_RS21145 Protein ID WP_000855692.1
Coordinates 4187352..4187642 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LKX03_RS21115 (4183302) 4183302..4183952 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
LKX03_RS21120 (4184409) 4184409..4184852 + 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LKX03_RS21125 (4185283) 4185283..4185732 + 450 WP_000381610.1 membrane protein -
LKX03_RS21130 (4185717) 4185717..4186064 + 348 WP_001669174.1 DUF1493 family protein -
LKX03_RS21135 (4186337) 4186337..4186663 - 327 WP_000393302.1 hypothetical protein -
LKX03_RS21140 (4186904) 4186904..4187082 + 179 Protein_4040 IS3 family transposase -
LKX03_RS21145 (4187352) 4187352..4187642 + 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
LKX03_RS21150 (4187639) 4187639..4188166 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LKX03_RS21155 (4188239) 4188239..4188444 - 206 Protein_4043 IS5/IS1182 family transposase -
LKX03_RS21160 (4188791) 4188791..4189447 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
LKX03_RS21165 (4189619) 4189619..4190140 - 522 WP_000858988.1 hypothetical protein -
LKX03_RS21170 (4190299) 4190299..4192866 + 2568 WP_001005807.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4188239..4188415 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T222426 WP_000971655.1 NZ_CP085987:4187639-4188166 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T222426 NZ_CP117852:848758-849249 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGAACCATCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT222426 WP_000855692.1 NZ_CP085987:4187352-4187642 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT222426 NZ_CP117852:848468-848761 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGTCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCACAGGCTTATCAGGAATTTCTCGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCACCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References