265902

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1108733..1109547 Replicon chromosome
Accession NZ_CP113535
Organism Salmonella enterica strain ZLQ

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag OXV11_RS05380 Protein ID WP_000971655.1
Coordinates 1108733..1109260 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag OXV11_RS05385 Protein ID WP_000855692.1
Coordinates 1109257..1109547 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV11_RS05360 (1104033) 1104033..1106600 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
OXV11_RS05365 (1106759) 1106759..1107280 + 522 WP_000858988.1 hypothetical protein -
OXV11_RS05370 (1107452) 1107452..1108108 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
OXV11_RS05375 (1108455) 1108455..1108660 + 206 Protein_1056 IS5/IS1182 family transposase -
OXV11_RS05380 (1108733) 1108733..1109260 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
OXV11_RS05385 (1109257) 1109257..1109547 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
OXV11_RS05390 (1109817) 1109817..1109995 - 179 Protein_1059 IS3 family transposase -
OXV11_RS05395 (1110236) 1110236..1110562 + 327 WP_000393302.1 hypothetical protein -
OXV11_RS05400 (1110835) 1110835..1111182 - 348 WP_001669174.1 DUF1493 family protein -
OXV11_RS05405 (1111167) 1111167..1111616 - 450 WP_000381610.1 membrane protein -
OXV11_RS05410 (1112047) 1112047..1112490 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
OXV11_RS05415 (1112947) 1112947..1113597 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - invH / invF / invG / invE / invA / invB 1108484..1118910 10426
flank IS/Tn - - 1108484..1108660 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T265902 WP_000971655.1 NZ_CP113535:c1109260-1108733 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT265902 WP_000855692.1 NZ_CP113535:c1109547-1109257 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References